An eco-friendly approach for the synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles via a multi-component condensation

被引：6
|
作者：
Mehrabi, Hossein [1 ]
Alizadeh-Bami, Farzaneh [1 ]
Meydani, Azam [1 ]
Besharat, Soheila [1 ]
机构：
[1] Vali E Asr Univ Rafsanjan, Dept Chem, Rafsanjan 77176, Iran
来源：
ARKIVOC | 2021年
关键词：
Multi-component condensation; 1,2,5-trisubstituted imidazole; 4-amino-1,2,5-tetrasubstituted imidazole; arylglyoxal; ethyl bromopyruvate; ONE-POT SYNTHESIS; POLYSUBSTITUTED IMIDAZOLES; CATALYST; AMINOIMIDAZOLE; DERIVATIVES; EFFICIENT; AGENTS; DRUG;
D O I：
10.24820/ark.5550190.p011.442
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles was demonstrated via a two-step cyclo-condensation reaction of aryl amines, carbonitriles, and ethyl bromopyruvate or aryl amines and arylglyoxals in ethanol heated under reflux in the presence of iron (III) chloride (FeCl3), and disodium phosphate (Na2HPO4) as catalysts, respectively. All the products were obtained in good to excellent yields and their structures were established from their spectroscopic data. [GRAPHICS] .
引用
收藏
页码：86 / 95
页数：10
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