Large-scale benchmark of Endeavour using MetaCore maps

被引：29

作者：

Schuierer, Sven ^{[1
]}

Tranchevent, Leon-Charles ^{[2
,3
]}

Dengler, Uwe ^{[1
]}

Moreau, Yves ^{[2
,3
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

[2] Katholieke Univ Leuven, Dept Elect Engn ESAT SCD, Leuven, Belgium

[3] Katholieke Univ Leuven, SymBioSys Ctr Computat Syst Biol, Leuven, Belgium

来源：

BIOINFORMATICS | 2010年 / 26卷 / 15期

关键词：

GENE PRIORITIZATION; GENOMIC DATA;

D O I：

10.1093/bioinformatics/btq307

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Endeavour is a tool that detects the most promising genes within large lists of candidates with respect to a biological process of interest and by combining several genomic data sources. We have benchmarked Endeavour using 450 pathway maps and 826 disease marker sets from MetaCore (TM) of GeneGo, Inc. containing a total of 9911 and 12 432 genes, respectively. We obtained an area under the receiver operating characteristic curves of 0.97 for pathway and of 0.91 for disease gene sets. These results indicate that Endeavour can be used to efficiently prioritize candidate genes for pathways and diseases.

引用

页码：1922 / 1923

页数：2

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