Il-4 and IL-13 act independently and synergistically to drive type 2 inflammation

被引:0
|
作者
Le Floc'H, Audrey [1 ]
Allinne, Jeanne [1 ]
Nagashima, Kirsten [1 ]
Scott, George [1 ]
Birchard, Dylan [1 ]
Asrat, Seblewongel [1 ]
Sleeman, Matthew [1 ]
Murphy, Andrew [1 ]
Orengo, Jamie [1 ]
机构
[1] Regeneron Pharmaceut, Tarrytown, NY USA
关键词
D O I
10.1183/13993003.congress-2019.PA5206
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
PA5206
引用
收藏
页数:2
相关论文
共 50 条
  • [1] IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline
    Scott, George
    Asrat, Seblewongel
    Allinne, Jeanne
    Lim, Wei Keat
    Nagashima, Kirsten
    Birchard, Dylan
    Srivatsan, Subhashini
    Ajithdoss, Dharani K.
    Oyejide, Adelekan
    Ben, Li-Hong
    Walls, Johnathon
    Le Floc'h, Audrey
    Yancopoulos, George D.
    Murphy, Andrew J.
    Sleeman, Matthew A.
    Orengo, Jamie M.
    CYTOKINE, 2023, 162
  • [2] Requirement for IL-13 independently of IL-4 in experimental asthma
    Grünig, G
    Warnock, M
    Wakil, AE
    Venkayya, R
    Brombacher, F
    Rennick, DM
    Sheppard, D
    Mohrs, M
    Donaldson, DD
    Locksley, RM
    Corry, DB
    SCIENCE, 1998, 282 (5397) : 2261 - 2263
  • [3] Requirement for IL-13 independently of IL-4 in experimental asthma
    Grunig, G
    Warnock, M
    Wakil, AE
    Venkayya, R
    Brombacher, F
    Rennick, DM
    Sheppard, D
    Mohrs, M
    Donaldson, DD
    Locksley, RM
    Corry, DB
    FASEB JOURNAL, 1999, 13 (04): : A318 - A318
  • [4] Asthma and CRSwNP: with dual inhibition of IL-4 and IL-13 against type 2 inflammation
    Eimer, Martina
    ALLERGO JOURNAL, 2023, 32 (07) : 70 - 70
  • [5] The role of Il-4 and Il-13 in RSV induced lung inflammation
    Patel, VK
    Srikiatkhachorn, A
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (02) : S83 - S83
  • [6] IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent
    Huang, H
    HuLi, J
    Chen, HJ
    BenSasson, SZ
    Paul, WE
    JOURNAL OF IMMUNOLOGY, 1997, 159 (08): : 3731 - 3738
  • [7] Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis
    Munitz, A.
    Brandt, E. B.
    Mingler, M.
    Finkelmant, F. D.
    Rothenberg, M. E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (20) : 7240 - 7245
  • [8] Structural similarity of IL-13 and IL-4
    Tang, JCT
    Cannon-Carlson, S
    Varnerin, J
    Tsarbopoulos, A
    Wylie, D
    FASEB JOURNAL, 1997, 11 (09): : A1361 - A1361
  • [9] Signaling interactions between IL-4 or IL-13 and leukotrienes in allergic inflammation
    Daines, M. O.
    Zornes, P. A.
    Hershey, G. K. Khurana
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (01) : S288 - S288
  • [10] Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation
    Le Floc'h, Audrey
    Allinne, Jeanne
    Nagashima, Kirsten
    Scott, George
    Birchard, Dylan
    Asrat, Seblewongel
    Bai, Yu
    Lim, Wei Keat
    Martin, Joel
    Huang, Tammy
    Potocky, Terra B.
    Kim, Jee H.
    Rafique, Ashique
    Papadopoulos, Nicholas J.
    Stahl, Neil
    Yancopoulos, George D.
    Murphy, Andrew J.
    Sleeman, Matthew A.
    Orengo, Jamie M.
    ALLERGY, 2020, 75 (05) : 1188 - 1204