New antimalarial lanostane triterpenes from a new isolate of Egyptian Ganoderma species

被引：9
|
作者：
Wahba, Amir E. [1 ,2 ]
El-Sayed, Ahmed K. A. [3 ]
El-Falal, Amira A. [3 ]
Soliman, Eman M. [3 ]
机构：
[1] Damietta Univ, Fac Sci, Chem Dept, New Damietta, Egypt
[2] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Neurosurg, Piscataway, NJ 08854 USA
[3] Damietta Univ, Fac Sci, Bot & Microbiol Dept, New Damietta, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2019年 / 28卷 / 12期
关键词：
Ganoderma; Triterpenes; Malaria; Ganoderic acid; Plasmodium falciparum; FRUITING BODIES;
D O I：
10.1007/s00044-019-02450-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new lanostane triterpenes named ganoderic acid AW1 (1) and ganoderic acid AW2 (2) were isolated from the fungal fruiting bodies of the cultivated new isolate of the Egyptian Ganoderma sp in addition to the known compounds ganomycine A (3), pinellic acid (4), and ergosterol peroxide (5). Their structures were elucidated by detailed analysis of their 1D and 2D-NMR data, as well as high-resolution mass spectroscopy. Ganoderic acid AW1 (1) showed good antimalarial activity against the chloroquine sensitive strain of Plasmodium falciparum with an IC50 value of 257.8 nM with no cytotoxicity up to the concentration of 9 mu M.
引用
收藏
页码：2246 / 2251
页数：6
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