Design, synthesis and DNA/RNA binding studies of nucleic acids comprising stereoregular and acyclic polycarbamate backbone: polycarbamate nucleic acids (PCNA)

被引：16

作者：

Madhuri, Vangala ^{[1
]}

Kumar, Vaijayanti A. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 16期

关键词：

CARBAMATE INTERNUCLEOSIDE LINKAGES; ANALOGS; RNA; OLIGONUCLEOTIDES; SEQUENCE; HYBRIDIZATION; NUCLEOSIDE; PNA; DNA; RECOGNITION;

D O I：

10.1039/c003405n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The designed, chiral, acyclic polycarbamate nucleic acids (PCNA) exhibited sequence and orientation specific binding to nucleic acids. Complexes of PCNA with DNA were as stable as PNA:DNA complexes and those with RNA were as stable as natural DNA:RNA complexes.

引用

页码：3734 / 3741

页数：8

共 50 条

[1] Design, synthesis and DNA/RNA binding studies of nucleic acids comprising stereoregular and acyclic polycarbamate backbone: polycarbamate nucleic acids (PCNA) (vol 8, pg 3734, 2010)
Madhuri, Vangala
Kumar, Vaijayanti A.
ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (24) : 5700 - 5700
[2] Backbone-extended pyrrolidine peptide nucleic acids (bepPNA):: design, synthesis and DNA/RNA binding studies
Govindaraju, T
Kumar, VA
CHEMICAL COMMUNICATIONS, 2005, (04) : 495 - 497
[3] Comparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO)
Kotikam, Venubabu
Fernandes, Moneesha
Kumar, Vaijayanti Anil
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2012, 14 (43) : 15003 - 15006
[4] Conformationally restricted cationic polyamide analogs of nucleic acids: Design, synthesis, and DNA/RNA binding studies
Kumar, VA
D'Costa, M
Lonkar, PS
Pallan, MPS
Ganesh, KN
PURE AND APPLIED CHEMISTRY, 2004, 76 (7-8) : 1599 - 1603
[5] Pyrrolidine carbamate nucleic acids: Synthesis and DNA binding studies
Meena
Kumar, VA
BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (16) : 3393 - 3399
[6] Probing Binding Preferences of DNA and RNA: Backbone Chirality of Thioacetamido-Linked Nucleic Acids and iso-Thioacetamido-Linked Nucleic Acids to Differentiate DNA versus RNA Selective Binding
Gokhale, Sachin S.
Gogoi, Khirud
Kumar, Vaijayanti A.
JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (21): : 7431 - 7434
[7] Boranopbosphate nucleic acids - A versatile DNA backbone
Rait, V
Sergueev, D
Summers, J
He, KZ
Huang, FQ
Krzyzanowska, B
Shaw, BR
NUCLEOSIDES & NUCLEOTIDES, 1999, 18 (6-7): : 1379 - 1380
[8] Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: Thermal stability studies
Filichev, VV
Christensen, UB
Pedersen, EB
Babu, BR
Wengel, J
CHEMBIOCHEM, 2004, 5 (12) : 1673 - 1679
[9] INFRARED STUDIES ON BACKBONE CONFORMATION OF NUCLEIC-ACIDS
BRAHMS, S
BRAHMS, J
PILET, J
ISRAEL JOURNAL OF CHEMISTRY, 1974, 12 (1-2) : 153 - 163
[10] Synthesis and Nucleic Acids Binding Properties of Diastereomeric Aminoethylprolyl Peptide Nucleic Acids (aepPNA)
Ngamwiriyawong, Patcharee
Vilaivan, Tirayut
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2011, 30 (02): : 97 - 112

← 1 2 3 4 5 →