Effects of ochratoxin A on micronucleus frequency in human lymphocytes

被引：16
|
作者：
Dönmez-Altuntas, H [1 ]
Hamurcu, Z
Imamoglu, N
Liman, BC
机构：
[1] Erciyes Univ, Fac Med, Dept Med Biol, TR-38039 Kayseri, Turkey
[2] Erciyes Univ, Fac Vet, Dept Pharmacol, TR-38039 Kayseri, Turkey
来源：
NAHRUNG-FOOD | 2003年 / 47卷 / 01期
关键词：
human lymphocytes; micronucleus; ochratoxin A;
D O I：
10.1002/food.200390005
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Ochratoxin A (OTA), a nephrotoxic and carcinogenic mycotoxin, was investigated to examine its potency to induce micronuclei (MN) in cultured human lymphocytes. Lymphocyte cultures were treated for the last 48 h with OTA at concentrations of 25 mum, 10 mum, 1 mum, 100 nm, 10 nm, 1 nm, and 100 pm and absolute ethanol. At the highest concentration, OTA was found to induce MN in cytokinesis-blocked lymphocytes (p < 0.05). The 25 muM OTA concentration also led to a clear decrease in the percentage of binucleated cells, probably due to cytotoxicity. OTA at the other concentrations tested did not induce MN frequency. These results indicate that a high concentration of OTA is genotoxic in cultured human lymphocytes.
引用
收藏
页码：33 / 35
页数：3
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