Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress

被引：226

作者：

Attard, GS ^{[1
]}

Templer, RH

Smith, WS

Hunt, AN

Jackowski, S

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Dept Child Hlth, Southampton SO17 1BJ, Hants, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[4] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

[5] Univ Tennessee, Dept Biochem, Memphis, TN 38163 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 16期

关键词：

D O I：

10.1073/pnas.160260697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.

引用

页码：9032 / 9036

页数：5

共 40 条

[1] Lipid regulation of CTP:phosphocholine cytidylytransferase: Electrostatic, hydrophobic, and synergistic interactions of anionic phospholipids and diacylglycerol [J].

Arnold, RS ;

Cornell, RB .

BIOCHEMISTRY, 1996, 35 (30) :9917-9924

[2] Apoptosis triggered by 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP:phosphocholine cytidylyltransferase [J].

Baburina, I ;

Jackowski, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (04) :2169-2173

[3] The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine [J].

Boggs, K ;

Rock, CO ;

Jackowski, S .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1998, 1389 (01) :1-12

[4] LYSOPHOSPHATIDYLCHOLINE AND 1-O-OCTADECYL-2-O-METHYL-RAC-GLYCERO-3-PHOSPHOCHOLINE INHIBIT THE CDP-CHOLINE PATHWAY OF PHOSPHATIDYLCHOLINE SYNTHESIS AT THE CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE STEP [J].

BOGGS, KP ;

ROCK, CO ;

JACKOWSKI, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) :7757-7764

[5] LYSOPHOSPHATIDYLCHOLINE ATTENUATES THE CYTOTOXIC EFFECTS OF THE ANTINEOPLASTIC PHOSPHOLIPID 1-O-OCTADECYL-2-O-METHYL-RAC-GLYCERO-3-PHOSPHOCHOLINE [J].

BOGGS, KP ;

ROCK, CO ;

JACKOWSKI, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (19) :11612-11618

[6]

CEVC G, 1985, BIOCHIM BIOPHYS ACTA, V814, P141, DOI 10.1016/0005-2736(85)90429-8

[7] The influence of cholesterol on phospholipid membrane curvature and bending elasticity [J].

Chen, Z ;

Rand, RP .

BIOPHYSICAL JOURNAL, 1997, 73 (01) :267-276

[8] LIPID REQUIREMENTS FOR THE AGGREGATION OF CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE IN RAT-LIVER CYTOSOL [J].

CHOY, PC ;

FARREN, SB ;

VANCE, DE .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1979, 57 (06) :605-612

[9] BINDING OF CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE TO LARGE UNILAMELLAR VESICLES [J].

CORNELL, R ;

VANCE, DE .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 919 (01) :37-48

[10] REGULATION OF CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE BY LIPIDS .2. SURFACE CURVATURE, ACYL CHAIN-LENGTH, AND LIPID-PHASE DEPENDENCE FOR ACTIVATION [J].

CORNELL, RB .

BIOCHEMISTRY, 1991, 30 (24) :5881-5888

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