Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams

被引：62

作者：

Yuan, Qianjia ^{[1
]}

Sigman, Matthew S. ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, 315 South 1400 East, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 21期

基金：

美国国家卫生研究院;

关键词：

QUATERNARY CARBON CENTERS; ASYMMETRIC-SYNTHESIS; ALKENYL ALCOHOLS; GAMMA; HYDROGENATION; CONSTRUCTION; ACTIVATION; INHIBITORS; ENAMIDES; KETONES;

D O I：

10.1021/jacs.8b02752

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this Communication, we describe the construction of chiral alpha,beta-unsaturated delta-lactams, widely used as pharmacophores, in high yields and excellent enantioselectivities using an oxidative relay Heck arylation reaction. This strategy also allows facile access to 7-substituted alpha,beta-unsaturated epsilon-lactam products and delta-lactams containing a tetrasubstituted nitrogen-bearing stereocenter.

引用

页码：6527 / 6530

页数：4

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