Structure and Function of Chromatin Remodelers

被引：81

作者：

Reyes, Alexis A. ^{[1
,2
]}

Marcum, Ryan D. ^{[1
]}

He, Yuan ^{[1
,2
,3
,4
]}

机构：

[1] Northwestern Univ, Dept Mol Biosci, 2205 Tech Dr, Evanston, IL 60208 USA

[2] Northwestern Univ, Interdisciplinary Biol Sci Program, 2205 Tech Dr, Evanston, IL 60208 USA

[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, 676 N St Clair, Chicago, IL 60611 USA

[4] Northwestern Univ, Chem Life Proc Inst, Evanston, IL 60208 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2021年 / 433卷 / 14期

关键词：

DNA-BINDING PROPERTIES; EXTRANUCLEOSOMAL DNA; PROMOTER NUCLEOSOMES; DISASSEMBLY RATHER; HISTONE H2AZ; SWI/SNF; YEAST; CHD1; TRANSCRIPTION; SWR1;

D O I：

10.1016/j.jmb.2021.166929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin remodelers act to regulate multiple cellular processes, such as transcription and DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers have been identified in yeast, each with non-redundant roles within the cell. There has been a recent surge in structural models of chromatin remodelers in complex with their nucleosomal substrate. These structural studies provide new insight into the mechanism of action for individual chromatin remodelers. In this review, we summarize available data for the structure and mechanism of action of the four chromatin remodeling complex families. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：10

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