Synthesis of pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine derivatives for antiviral evaluation

被引：108

作者：

Shamroukh, Ahmed H. ^{[1
]}

Zaki, Magdi E. A. ^{[1
]}

Morsy, Eman M. H. ^{[1
]}

Abdel-Motti, Faiza M. ^{[1
]}

Abdel-Megeid, Farouk M. E. ^{[1
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo 12622, Egypt

来源：

ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 05期

关键词：

acyclic nucleosides; antiviral activities; pyranopyrazoles; pyrazoles; pyrazolopyranopyrimidines;

D O I：

10.1002/ardp.200700005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-Amino-3-methyl-4-(4-nitrophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (1) was used as a precursor for preparation of some novel 3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4 ',3 ':5,6]pyrano[2,3-d]pyrimidine derivatives 3-6, and some of their corresponding N-2- and C-5-S-acyclic nucleosides 7 and 8. Furthermore, the preparation of 5-aniino-1-[3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4 ',3 ':5,6]pyrano[2,3-d]pyrimidin-5-yl]-1H-pyrazole derivatives 10-16 were described. Some of the prepared products were selected and tested for antiviral activity against Herpes Simplex Virus type-1 (HSV-1).

引用

页码：236 / 243

页数：8

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