Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma (LUAC) with distinct biology and therapeutic vulnerabilities

被引：0

作者：

Skoulidis, Ferdinandos ^{[1
]}

Byers, Lauren ^{[1
]}

Diao, Lixia ^{[1
]}

Papadimitrakopoulou, Vassiliki ^{[1
]}

Tong, Pan ^{[1
]}

Izzo, Julie ^{[1
]}

Behrens, Carmen ^{[1
]}

Kadara, Humam ^{[1
]}

Parra, Edwin R. ^{[1
]}

Rodriguez-Canales, Jaime ^{[1
]}

Zhang, Jianjun ^{[1
]}

Giri, Uma ^{[1
]}

Gudikote, Jayanthi ^{[1
]}

Cortez, Maria Angelica ^{[1
]}

Yang, Chao ^{[1
]}

Fan, You Hong ^{[1
]}

Peyton, Michael ^{[2
]}

Girard, Luc ^{[2
]}

Coombes, Kevin R. ^{[3
]}

Toniatti, Carlo ^{[1
]}

Heffernan, Timothy P. ^{[1
]}

Choi, Murim ^{[4
]}

Frampton, Garrett M. ^{[5
]}

Miller, Vincent ^{[5
]}

Weinstein, John N. ^{[1
]}

Herbst, Roy S. ^{[6
]}

Wong, Kwok-Kin ^{[7
]}

Zhang, Jianhua ^{[1
]}

Sharma, Padmanee ^{[1
]}

Mills, Gordon M. ^{[1
]}

Hong, Waun Ki ^{[1
]}

Minna, John D. ^{[2
]}

Allison, James P. ^{[1
]}

Futreal, Andrew ^{[1
]}

Wang, Jing ^{[1
]}

Wistuba, Ignacio ^{[1
]}

Heymach, John V. ^{[1
]}

机构：

[1] UT MD Anderson Canc Ctr, Houston, TX USA

[2] UT Southwestern Med Ctr, Dallas, TX USA

[3] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA

[4] Seoul Natl Univ, Coll Med, Seoul, South Korea

[5] Fdn Med, Cambridge, MA USA

[6] Yale Canc Ctr, Yale, CT USA

[7] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CANCER RESEARCH | 2015年 / 75卷

关键词：

D O I：

10.1158/1538-7445.AM2015-968

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

968

引用

页数：2

共 16 条

[1] Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
Skoulidis, Ferdinandos
Byers, Lauren A.
Diao, Lixia
Papadimitrakopoulou, Vassiliki A.
Tong, Pan
Izzo, Julie
Behrens, Carmen
Kadara, Humam
Parra, Edwin R.
Canales, Jaime Rodriguez
Zhang, Jianjun
Giri, Uma
Gudikote, Jayanthi
Cortez, Maria A.
Yang, Chao
Fan, Youhong
Peyton, Michael
Girard, Luc
Coombes, Kevin R.
Toniatti, Carlo
Heffernan, Timothy P.
Choi, Murim
Frampton, Garrett M.
Miller, Vincent
Weinstein, John N.
Herbst, Roy S.
Wong, Kwok-Kin
Zhang, Jianhua
Sharma, Padmanee
Mills, Gordon B.
Hong, Waun K.
Minna, John D.
Allison, James P.
Futreal, Andrew
Wang, Jing
Wistuba, Ignacio I.
Heymach, John V.
CANCER DISCOVERY, 2015, 5 (08) : 860 - 877
[2] Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non-Small Cell Lung Cancer
Arbour, Kathryn C.
Jordan, Emmett
Kim, Hyunjae Ryan
Dienstag, Jordan
Yu, Helena A.
Sanchez-Vega, Francisco
Lito, Piro
Berger, Michael
Solit, David B.
Hellmann, Matthew
Kris, Mark G.
Rudin, Charles M.
Ni, Ai
Arcila, Maria
Ladanyi, Marc
Riely, Gregory J.
CLINICAL CANCER RESEARCH, 2018, 24 (02) : 334 - 340
[3] IMPACT OF CO-OCCURRING GENETIC EVENTS ON THE SIGNALING LANDSCAPE OF KRAS-MUTANT LUNG ADENOCARCINOMA.
Skoulidis, Ferdinandos
Diao, Lixia
Fan, Youhong
Minna, John D.
Weinstein, John N.
Heymach, John V.
Wang, Jing
Byers, Lauren A.
JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S348 - S348
[4] Integrative analysis reveals distinct subtypes with therapeutic implications in KRAS-mutant lung adenocarcinoma
Liu, Ke
Guo, Jintao
Liu, Kuai
Fan, Peiyang
Zeng, Yuanyuan
Xu, Chaoqun
Zhong, Jiaxin
Li, Qiyuan
Zhou, Ying
EBIOMEDICINE, 2018, 36 : 196 - 208
[5] Co-Occurring Genomic Alterations in EGFR Altered Chinese Lung Adenocarcinoma Patients
Wang, M.
Zhong, H.
Dai, L.
Wang, L.
Shen, P.
Wang, Y.
Jiang, D.
Zheng, M.
Wu, D.
Shi, F.
Wang, K.
Li, C.
Chen, H.
Dong, Y.
Shi, W.
Wang, K.
Yao, M.
JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (10) : S913 - S913
[6] Novel co-occurring genomic alterations associated with prediction and prognosis in lung adenocarcinoma
Zhao, X.
Zheng, Z.
Xiao, L.
Li, F.
Wu, K.
ANNALS OF ONCOLOGY, 2020, 31 : S1361 - S1361
[7] Impact of co-occurring genetic events on RAS signaling diversification in NF1-mutant lung adenocarcinoma (LUAC)
Skoulidis, Ferdinandos
Tong, Pan
Wang, Jing
Heymach, John V.
CANCER RESEARCH, 2015, 75
[8] Impact of Major Co-Mutations on the Immune Contexture and Response of KRAS-Mutant Lung Adenocarcinoma to Immunotherapy
Skoulidis, Ferdinandos
Elamin, Yasir
Papadimitrakopoulou, Vassiliki
Tong, Pan
Wang, Jing
Lewis, Jeff
Rinsurongkawong, Waree
Chu, Caleb
Roarty, Emily
Zhang, Jianjun
Tran, Hai
Rodriguez-Canales, Jaime
Parra, Edwin
Behrens, Carmen
Kadara, Humam
Wistuba, Ignacio
Heymach, John
JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S361 - S362
[9] Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Skoulidis, Ferdinandos
Heymach, John, V
NATURE REVIEWS CANCER, 2019, 19 (09) : 495 - 509
[10] Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Ferdinandos Skoulidis
John V. Heymach
Nature Reviews Cancer, 2019, 19 : 495 - 509

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