Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix

被引：1
|
作者：
Bandiera, A
Bonifacio, D
Manfioletti, G
Mantovani, F
Rustighi, A
Zanconati, F
Fusco, A
Di Bonito, L
Giancotti, V
机构：
[1] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy
[2] Univ Trieste, Osped Maggiore, Ist Anat & Istol Patol, I-34125 Trieste, Italy
[3] Univ Reggio Calabria, Fac Med & Chirurg Catanzaro, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy
来源：
CANCER RESEARCH | 1998年 / 58卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of nuclear proteins high mobility group (HMG) I and HMGY was investigated in intraepithelial and invasive lesions of the uterine cervix. Human carcinoma cell lines C-4I, ME-180, and CaSki were used for testing protein expression in neoplastic cells from the cervix. Morphological grading of the dysplasias (GIN 1, CIN 2, and CIN 3) and invasive carcinomas from formalin-fixed paraffin-embedded samples parallels the degree of nuclear immunostaining obtained using a polyclonal antibody raised against the amino-terminal region of HMGI(Y) proteins, The immunostaining obtained with HMGI(Y) antibody was compared with that observed using the antibody Ki-67, and the results were similar. We suggest the use of HMGI(Y) antibody in clinical oncology as a useful marker of intraepithelial lesions and invasive carcinomas.
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收藏
页码：426 / 431
页数：6
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