Dysfunction in the neural circuitry of emotion regulation - A possible prelude to violence

被引:1277
作者
Davidson, RJ [1 ]
Putnam, KM
Larson, CL
机构
[1] Univ Wisconsin, Lab Affect Neurosci, Madison, WI 53706 USA
[2] Univ Wisconsin, WM Keck Lab Funct Brain Imaging & Behav, Madison, WI 53706 USA
关键词
D O I
10.1126/science.289.5479.591
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Emotion is normally regulated in the human brain by a complex circuit consisting of the orbital frontal cortex, amygdala, anterior cingulate cortex, and several other interconnected regions. There are both genetic and environmental contributions to the structure and function of this circuitry. We posit that impulsive aggression and violence arise as a consequence of faulty emotion regulation. Indeed, the prefrontal cortex receives a major serotonergic projection, which is dysfunctional in individuals who show impulsive violence. Individuals vulnerable to faulty regulation of negative emotion are at risk for violence and aggression. Research on the neural circuitry of emotion regulation suggests new avenues of intervention for such at-risk populations.
引用
收藏
页码:591 / 594
页数:4
相关论文
共 75 条
[1]  
Abercrombie HC, 1996, PSYCHOPHYSIOLOGY, V33, pS17
[2]   IMPAIRED RECOGNITION OF EMOTION IN FACIAL EXPRESSIONS FOLLOWING BILATERAL DAMAGE TO THE HUMAN AMYGDALA [J].
ADOLPHS, R ;
TRANEL, D ;
DAMASIO, H ;
DAMASIO, A .
NATURE, 1994, 372 (6507) :669-672
[3]   Impairment of social and moral behavior related to early damage in human prefrontal cortex [J].
Anderson, SW ;
Bechara, A ;
Damasio, H ;
Tranel, D ;
Damasio, AR .
NATURE NEUROSCIENCE, 1999, 2 (11) :1032-1037
[4]  
[Anonymous], 1999, HDB COGNITION EMOTIO
[5]  
[Anonymous], 2000, SER AFFECTIVE SCI
[6]   Impulsive and premeditated aggression: a factor analysis of self-reported acts [J].
Barratt, ES ;
Stanford, MS ;
Dowdy, L ;
Liebman, MJ ;
Kent, TA .
PSYCHIATRY RESEARCH, 1999, 86 (02) :163-173
[7]   Deciding advantageously before knowing the advantageous strategy [J].
Bechara, A ;
Damasio, H ;
Tranel, D ;
Damasio, AR .
SCIENCE, 1997, 275 (5304) :1293-1295
[8]  
BERKOWITZ LA, IN PRESS HDB AFFECTI
[9]   Sex difference in 5HT(2) receptor in the living human brain [J].
Biver, F ;
Lotstra, F ;
Monclus, M ;
Wikler, D ;
Damhaut, P ;
Mendlewicz, J ;
Goldman, S .
NEUROSCIENCE LETTERS, 1996, 204 (1-2) :25-28
[10]   The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control [J].
Bjork, JM ;
Dougherty, DM ;
Moeller, FG ;
Cherek, DR ;
Swann, AC .
PSYCHOPHARMACOLOGY, 1999, 142 (01) :24-30