Cause-specific death assessment of patients with stage I small-cell lung cancer: a competing risk analysis

被引：8

作者：

Liu, Jiaqing ^{[1
,2
,3
,4
]}

Zhou, Huaqiang ^{[1
,2
,3
,4
]}

Zhang, Yaxiong ^{[1
,2
,3
]}

Fang, Wenfeng ^{[1
,2
,3
]}

Yang, Yunpeng ^{[1
,2
,3
]}

Hong, Shaodong ^{[1
,2
,3
]}

Chen, Gang ^{[1
,2
,3
]}

Zhao, Shen ^{[1
,2
,3
]}

Chen, Xi ^{[1
,2
,3
]}

Zhang, Zhonghan ^{[1
,2
,3
]}

Xian, Wei ^{[4
]}

Shen, Jiayi ^{[4
]}

Huang, Yan ^{[1
,2
,3
]}

Zhao, Hongyun ^{[1
,2
,3
]}

Zhang, Li ^{[1
,2
,3
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China

[2] State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[3] Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 21期

基金：

国家重点研发计划;

关键词：

cancer-specific death; competing risk nomogram; SCLC; SEER; SURVIVAL; SURGERY; COMORBIDITY; NOMOGRAM; OUTCOMES; LIMITATIONS; MORTALITY; PREDICT; IMPACT; NEED;

D O I：

10.2217/fon-2018-0888

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Stage I small-cell lung cancer (SCLC) is a potentially curable disease that needs timely and multidisciplinary management. The aim of this study was to evaluate the probability of cause-specific mortality for patients with stage I SCLC. Material & methods: We identified patients in the SEER database and constructed a proportional subdistribution hazard model to evaluate cancer-specific mortality. A nomogram was built based on Fine and Gray competing risk regression model. Results:A total of864 stage I SCLC patients were identified. The 5-year cumulative incidence of SCLC-specific mortality was 56.2%, while that for other causes of death was 17.3%. The c-index for the prognostic prediction model was 0.66. Besides, the nomogram was well calibrated. Conclusion: Our nomogram might serve as a reference for clinicians when evaluating the prognosis of stage I SCLC.

引用

页码：2479 / 2488

页数：10

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