KRAS RNAi therapy in preclinical models of pancreatic cancer sensitizes tumors to checkpoint blockade by affecting the tumor microenvironment

被引：0
|
作者：
Ganesh, Shanthi [1 ]
Shui, Serena [1 ]
Craig, Kevin [1 ]
Wang, Weimin [1 ]
Brown, Bob D. [1 ]
Abrams, Marc [1 ]
机构：
[1] Dicerna Pharmaceut Inc, Cambridge, MA USA
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2019-1502
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1502
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Immunogenic Chemotherapy Sensitizes Renal Cancer to Immune Checkpoint Blockade Therapy in Preclinical Models
    Cui, Shujin
    MEDICAL SCIENCE MONITOR, 2017, 23 : 3360 - 3366
  • [2] Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment
    Chiara Falcomatà
    Stefanie Bärthel
    Sebastian A. Widholz
    Christian Schneeweis
    Juan José Montero
    Albulena Toska
    Jonas Mir
    Thorsten Kaltenbacher
    Jeannine Heetmeyer
    Jonathan J. Swietlik
    Jing-Yuan Cheng
    Bianca Teodorescu
    Oliver Reichert
    Constantin Schmitt
    Kathrin Grabichler
    Andrea Coluccio
    Fabio Boniolo
    Christian Veltkamp
    Magdalena Zukowska
    Angelica Arenas Vargas
    Woo Hyun Paik
    Moritz Jesinghaus
    Katja Steiger
    Roman Maresch
    Rupert Öllinger
    Tim Ammon
    Olga Baranov
    Maria S. Robles
    Julia Rechenberger
    Bernhard Kuster
    Felix Meissner
    Maximilian Reichert
    Michael Flossdorf
    Roland Rad
    Marc Schmidt-Supprian
    Günter Schneider
    Dieter Saur
    Nature Cancer, 2022, 3 : 318 - 336
  • [3] Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
    Pfirschke, Christina
    Engblom, Camilla
    Rickelt, Steffen
    Cortez-Retamozo, Virna
    Garris, Christopher
    Pucci, Ferdinando
    Yamazaki, Takahiro
    Poirier-Colame, Vichnou
    Newton, Andita
    Redouane, Younes
    Lin, Yi-Jang
    Wojtkiewicz, Gregory
    Iwamoto, Yoshiko
    Mino-Kenudson, Mari
    Huynh, Tiffany G.
    Hynes, Richard O.
    Freeman, Gordon J.
    Kroemer, Guido
    Zitvogel, Laurence
    Weissleder, Ralph
    Pittet, Mikael J.
    IMMUNITY, 2016, 44 (02) : 343 - 354
  • [4] Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment
    Falcomata, Chiara
    Baerthel, Stefanie
    Widholz, Sebastian A.
    Schneeweis, Christian
    Montero, Juan Jose
    Toska, Albulena
    Mir, Jonas
    Kaltenbacher, Thorsten
    Heetmeyer, Jeannine
    Swietlik, Jonathan J.
    Cheng, Jing-Yuan
    Teodorescu, Bianca
    Reichert, Oliver
    Schmitt, Constantin
    Grabichler, Kathrin
    Coluccio, Andrea
    Boniolo, Fabio
    Veltkamp, Christian
    Zukowska, Magdalena
    Vargas, Angelica Arenas
    Paik, Woo Hyun
    Jesinghaus, Moritz
    Steiger, Katja
    Maresch, Roman
    Oellinger, Rupert
    Ammon, Tim
    Baranov, Olga
    Robles, Maria S.
    Rechenberger, Julia
    Kuster, Bernhard
    Meissner, Felix
    Reichert, Maximilian
    Flossdorf, Michael
    Rad, Roland
    Schmidt-Supprian, Marc
    Schneider, Guenter
    Saur, Dieter
    NATURE CANCER, 2022, 3 (03) : 318 - +
  • [5] Remodeling of the Tumor Microenvironment Through PAK4 Inhibition Sensitizes Tumors to Immune Checkpoint Blockade
    Abril-Rodriguez, Gabriel
    Torrejon, Davis Y.
    Karin, Daniel
    Campbell, Katie M.
    Medina, Egmidio
    Saco, Justin D.
    Galvez, Mildred
    Champhekar, Ameya S.
    Perez-Garcilazo, Ivan
    Baselga-Carretero, Ignacio
    Singh, Jas
    Comin-Anduix, Begona
    Puig-Saus, Cristina
    Ribas, Antoni
    CANCER RESEARCH COMMUNICATIONS, 2022, 2 (10): : 1214 - 1228
  • [6] Ablative Radiotherapy Reprograms the Tumor Microenvironment of a Pancreatic Tumor in Favoring the Immune Checkpoint Blockade Therapy
    Lee, Yu-Hung
    Yu, Ching-Fang
    Yang, Ying-Chieh
    Hong, Ji-Hong
    Chiang, Chi-Shiun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (04) : 1 - 14
  • [7] RNAi-mediated β-catenin inhibition sensitizes noninflamed tumors to immune checkpoint blockade
    Ganesh, Shanthi
    Shui, Serena
    Wang, Weimin
    Brown, Bob D.
    Abrams, Marc
    CANCER IMMUNOLOGY RESEARCH, 2018, 6 (09)
  • [8] Inflammation-Regulated Nanodrug Sensitizes Hepatocellular Carcinoma to Checkpoint Blockade Therapy by Reprogramming the Tumor Microenvironment
    Wang, TianCheng
    Lin, MinZhao
    Mao, JunJie
    Tian, LiRong
    Gan, HaiRun
    Hu, XinYan
    Yan, LeYe
    Long, HaoYu
    Cai, JianXun
    Zheng, XiaoDi
    Xiao, YuDong
    Li, Dan
    Shuai, XinTao
    Pang, PengFei
    ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (44) : 49542 - 49554
  • [9] Immunogenic chemotherapy sensitizes non-small cell lung cancer to immune checkpoint blockade therapy in preclinical models.
    Lu, Jun
    Zhu, Ying
    Wang, Jiashun
    Wang, Lufeng
    Chen, Yikai
    Cai, Weipeng
    Yuan, Jinquan
    Wang, Xiaokang
    BIOMEDICAL RESEARCH-INDIA, 2017, 28 (02): : 828 - 834
  • [10] Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors
    Wei, Yongkun
    Liu, Minghui
    Yen, Er-Yen
    Yao, Jun
    Nguyen, Phuoc T.
    Wang, Xiaofei
    Yang, Zecheng
    Yousef, Abdelrahman
    Pan, Dean
    Jin, Yanqing
    Theady, Madelaine S.
    Park, Jangho
    Cai, Yiming
    Takeda, Mitsunobu
    Vasquez, Matthew
    Zhou, Yong
    Zhao, Hong
    Viale, Andrea
    Wang, Huamin
    Zhao, Dan
    DePinho, Ronald A.
    Yao, Wantong
    Ying, Haoqiang
    CANCER RESEARCH, 2024, 84 (06)
12345