Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan

被引：112

作者：

Kim, Eun Hee

Ahn, Yangkyu ^{[1
]}

Lee, Hyo Sook

机构：

[1] Korean Intellectual Property Off, Pharmaceut Examinat Div, Taejon, South Korea

[2] Korea Inst Geosci & Resources, Nano Mat Grp, Taejon, South Korea

来源：

JOURNAL OF ALLOYS AND COMPOUNDS | 2007年 / 434卷

关键词：

superparamagnetic iron oxide; nanoparticles; sonochemical method; ferrofluid; embolic material;

D O I：

10.1016/j.jallcom.2006.08.311

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Microspheres composed of superparamagnetic iron oxide (SPIO; Fe3O4; magnetite) nanoparticles and chitosan were developed as a novel MRI-detectable embolic material. Spherical SPIO nanoparticles were synthesized and embedded in polyglucosamine (chitosan) by sonochemical method. The ferrofluid, solution of SPIO-embedded chitosan, was sprayed on the surface of an alkali solution with a nozzle to produce SPIO-chitosan microspheres, from which 100-150 mu m microspheres were sifted out. The sifted microspheres were injected into the blood vessel leading to the kidney of a New Zealand white rabbit via an angiographic catheter in vivo, and they appeared to be detected in MR images of the kidney. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：633 / 636

页数：4

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Pharmaceutical Examination Division, The Korean Intellectual Property Office, Gov. Complex, Daejeon, Korea, Republic of
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