Randomisation of Relapsed and Refractory High-Risk Neuroblastoma Patients Treated with Long-Term Infusion of Anti-GD2 Antibody Dinutuximab Beta with or Without Subcutaneous Interleukin-2, A SIOPEN Study

被引:0
|
作者
Lode, H. [1 ]
Valteau-Couanet, D. [2 ]
Gray, J. [3 ]
Luksch, R. [4 ]
Wieczorek, A. [5 ]
Castel, V. [6 ]
Ash, S. [7 ]
Owens, C. [8 ]
Laureys, G. [9 ]
Papadakis, V. [10 ]
Garaventa, A. [11 ]
Manzitti, C. [11 ]
Siebert, N. [1 ]
Troschke-Meurer, S. [1 ]
Glogova, E. [12 ]
Poetschger, U. [12 ]
Ladenstein, R. [12 ]
机构
[1] Univ Med Greifswald, Pediat Hematol & Oncol, Greifswald, Germany
[2] Paris Sud Univ, Gustave Roussy, Children & Adolescent Oncol Dept, Paris, France
[3] Univ Southampton, Pediat Oncol, Southampton, Hants, England
[4] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol, Milan, Italy
[5] Jagiellonian Univ, Coll Med, Pediat Hematol Oncol, Krakow, Poland
[6] Hosp Univ & Politecn La Fe, Pediat Oncol, Valencia, Spain
[7] Tel Aviv Univ, Sackler Fac Med, Schneider Childrens Med Ctr Israel, Petah Tiqwa, Israel
[8] Our Ladys Childrens Hosp Crumlin, Pediat Haematol Oncol, Dublin, Ireland
[9] Univ Hosp Ghent, Pediat Oncol, Ghent, Belgium
[10] Agia Sofia Childrens Hosp, Dept Pediat Hematol Oncol, Athens, Greece
[11] IRCCS Ist Giannina Gaslini, Oncol Unit, Genoa, Italy
[12] St Anna Kinderkrebsforsch, CCRI, Vienna, Austria
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
FP054 SIOP
引用
收藏
页码:S34 / S35
页数:2
相关论文
共 50 条
  • [1] Randomized use of anti-GD2 antibody dinutuximab beta (DB) long-term infusion with and without subcutaneous interleukin-2 (sclL-2) in high-risk neuroblastoma patients with relapsed and refractory disease: Results from the SIOPEN LTI-trial.
    Lode, Holger N.
    Valteau-Couanet, Dominique
    Gray, Juliet
    Luksch, Roberto
    Wieczorek, Aleksandra
    Castel, Victoria
    Ash, Shifra
    Laureys, Genevieve
    Papadakis, Vassilios
    Owens, Cormac
    Garaventa, Alberto
    Manzitti, Carla
    Siebert, Nikolai
    Troschke-Meurer, Sascha
    Glogova, Evgenia
    Poetschger, Ulrike
    Ladenstein, Ruth Lydia
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [2] SINGLE AGENT ACTIVITY OF THE ANTI-GD2 ANTIBODY DINUTUXIMAB BETA LONG-TERM INFUSION IN HIGH-RISK NEUROBLASTOMA PATIENTS WITH RELAPSED AND REFRACTORY DISEASE. A MULTICENTER PHASE II TRIAL
    Lode, Holger
    Ehlert, Karoline
    Huber, Stephanie
    Siebert, Nikolai
    Troschke-Meurer, Sascha
    Zumpe, Maxi
    Loibner, Hans
    Ladenstein, Ruth
    PEDIATRIC BLOOD & CANCER, 2022, 69
  • [3] Dinutuximab: An Anti-GD2 Monoclonal Antibody for High-Risk Neuroblastoma
    Ploessl, Cady
    Pan, Alice
    Maples, Kathryn T.
    Lowe, Denise K.
    ANNALS OF PHARMACOTHERAPY, 2016, 50 (05) : 416 - 422
  • [4] Long-term infusion of anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 (IL2) activity and efficacy in high-risk relapsed/refractory neuroblastoma patients.
    Lode, Holger N.
    Valteau-Couanet, Dominique
    Garaventa, Alberto
    Gray, Juliet
    Castel, Victoria
    Yaniv, Isaac
    Siebert, Nikolai
    Jensen, Christian
    Endres, Stefanie
    Pill, Lena
    Eger, Christin
    Seidel, Diana
    Juettner, Madlen
    Kietz, Silke
    Ehlert, Karoline
    Janzek, Evelyne
    Loibner, Hans
    Mueller, Ina
    Ladenstein, Ruth L.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [5] Single-agent activity of the anti-GD2 antibody dinutuximab beta given as a long-term infusion in relapsed and refractory neuroblastoma (APN311-304)
    Lode, Holger N.
    Ehlert, Karoline
    Huber, Stephanie
    Siebert, Nikolai
    Troschke-Meurer, Sascha
    Zumpe, Maxi
    Loibner, Hans
    Ladenstein, Ruth Lydia
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [6] Randomization of dose-reduced subcutaneous interleukin-2 (scIL2) in maintenance immunotherapy (IT) with anti-GD2 antibody dinutuximab beta (DB) long-term infusion (LTI) in front line high-risk neuroblastoma patients: Early results from the HR-NBL1/SIOPEN trial.
    Ladenstein, Ruth Lydia
    Poetschger, Ulrike
    Valteau-Couanet, Dominique
    Gray, Juliet
    Luksch, Roberto
    Balwierz, Walentyna
    Castel, Victoria
    Ash, Shifra
    Popovic, Maja Beck
    Laureys, Genevieve
    Chan, Godfrey Chi Fung
    Ruud, Ellen
    Vettenranta, Kim
    Owens, Cormac
    Schroeder, Henrik
    Loibner, Hans
    Ambros, Peter F.
    Sarnacki, Sabine
    Boterberg, Tom
    Lode, Holger N.
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [7] Inflammatory response and treatment tolerance of long-term infusion of the anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 in patients with high-risk neuroblastoma
    Ceylan, Kiraz
    Jahns, Luciana J.
    Lode, Bjoern N.
    Ehlert, Karoline
    Kietz, Silke
    Troschke-Meurer, Sascha
    Siebert, Nikolai
    Lode, Holger N.
    PEDIATRIC BLOOD & CANCER, 2018, 65 (06)
  • [8] Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO
    Mueller, Ina
    Ehlert, Karoline
    Endres, Stefanie
    Pill, Lena
    Siebert, Nikolai
    Kietz, Silke
    Brock, Penelope
    Garaventa, Alberto
    Valteau-Couanet, Dominique
    Janzek, Evelyne
    Hosten, Norbert
    Zinke, Andreas
    Barthlen, Winfried
    Varol, Emine
    Loibner, Hans
    Ladenstein, Ruth
    Lode, Holger N.
    MABS, 2018, 10 (01) : 55 - 61
  • [9] Immune activation and clinical responses following long-term infusion of anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 in high-risk neuroblastoma patients.
    Lode, Holger N.
    Jensen, Christian
    Endres, Stefanie
    Pill, Lena
    Siebert, Nikolai
    Kietz, Silke
    Ehlert, Karoline
    Brock, Penelope
    Valteau-Couanet, Dominique
    Janzek, Evelyne
    Loibner, Hans
    Ladenstein, Ruth L.
    Mueller, Ina
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [10] Immune activation, clinical response and survival following long-term infusion of anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 in high-risk neuroblastoma patients
    Lode, Holger
    Jensen, Christian
    Siebert, Nikolai
    Kietz, Silke
    Ehlert, Karoline
    Mueller, Ina
    Ladenstein, Ruth
    Janzek, Evelyne
    Loibner, Hans
    CANCER RESEARCH, 2014, 74 (19)