Catalytic enantioselective synthesis of chiral 4-hydroxy 4′-substituted pyrazolones by the vinylogous aldol reaction of pyrazole-4,5-diones with 3-alkylidene-2-oxindoles

被引：2

作者：

Kumar, Krishna ^{[1
]}

Singh, Bhuvnesh ^{[1
]}

Hore, Soumyadip ^{[1
]}

Singh, Ravi P. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 31期

关键词：

CONSTRUCTION; OXINDOLES;

D O I：

10.1039/d0nj05886f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, a bifunctional quinine-derived benzamide catalyzed direct enantioselective vinylogous aldol reaction between 3-alkylidene-2-oxindoles and pyrazole-4,5-diones has been developed. This challenging protocol has been achieved via the H-bonding dual activation mode of the catalyst. Highly functional rich pyrazolone moieties having an oxindole core have been obtained with an excellent E/Z (>19 : 1), and high yields along with moderate enantioselectivity.

引用

页码：13747 / 13750

页数：4

共 16 条

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