Approaches to short-acting neuromuscular blocking agents: Nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters

被引：13
|
作者：
Dhar, NC
Maehr, RB
Masterson, LA
Midgley, JM
Stenlake, JB
Wastila, WB
机构：
[1] UNIV STRATHCLYDE,DEPT PHARMACEUT SCI,GLASGOW G1 1XW,LANARK,SCOTLAND
[2] BURROUGHS WELLCOME CO,WELLCOME RES LABS,RES TRIANGLE PK,NC 27709
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 02期
关键词：
D O I：
10.1021/jm950477z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nonsymmetrical bisquaternary mono- and diesters combining the potency-enhancing properties of the (1R)-laudanosinium group with a second unhindered quaternary ammonium moiety have been studied as a means of promoting short action with high-potency neuromuscular block. Atracurium-related nonsymmetrical diesters showed high potency, freedom from vagal blockade at neuromuscular blocking doses, and short action. Nonsymmetrical monoesters were short acting but showed varying degrees of vagal block.
引用
收藏
页码：556 / 561
页数：6
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