Psychopathology and sleep. I. Schizophrenia

This paper reviews the studies about sleep and schizophrenia, grouped into three categories: polysomnographic abnormalities of slow wave sleep, REM sleep alterations and, finally, effects of sleep deprivation in schizophrenic patients. Although it has not been consistently described, one of the most usually findings observed is a reduction of slow wave sleep. The pathophysiological significance of these deficits in schizophrenia remains unclear. In relation to REM sleep, the most commonly result reported has been a shortening of REM latency. On the other hand, an interesting finding in this condition is the existence of a weaker REM rebound following REM sleep deprivation. However, many of the changes in polysomnographic parameters in schizophrenic patients seem to be dependent on clinical course of the disorder and may be also influenced by the pharmacological treatment received.