15d-Prostaglandin J2 Enhancement of Nerve Growth Factor-Induced Neurite Outgrowth Is Blocked by the Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells (CRTH2) Antagonist CAY10471 in PC12 Cells

被引：18
|
作者：
Hatanaka, Michiyoshi [1 ]
Shibata, Norihiro [1 ]
Shintani, Norihito [1 ]
Haba, Ryota [1 ]
Hayata, Atsuko [1 ,2 ]
Hashimoto, Hitoshi [1 ,2 ,3 ,4 ]
Baba, Akemichi [1 ]
机构：
[1] Osaka Univ, Lab Mol Neuropharmacol, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Dept Expt Dis Model, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Grad Sch Med, Suita, Osaka 5650871, Japan
[3] Osaka Univ, United Grad Sch Child Dev, Kanazawa Univ, Suita, Osaka 5650871, Japan
[4] Hamamatsu Univ Sch Med, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 113卷 / 01期
基金：
日本学术振兴会;
关键词：
chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2); nerve growth factor (NGF); neurite outgrowth; ACTIVATED PROTEIN-KINASE; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); P38; PACAP; MICE;
D O I：
10.1254/jphs.10001SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The chemoattractant receptor homologous molecule expressed on T-helper type 2 cells (CRTH2) is the most recently identified prostaglandin (PG) receptor for both PGD(2) and 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)). We examined the mechanism by which 15d-PGJ(2) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. CAY10471 (CRTH2 antagonist) inhibited both the neurite-promotion and p38 mitogen-activated protein (MAP) kinase phosphorylation induced by 15d-PGJ(2). In contrast, 13,14-dihydro-15-keto-PGD(2) (DK-PGD(2)) (selective CRTH2 agonist) stimulated its phosphorylation but failed to produce neurite-promoting effects. These suggest, for the first time, the action of 15d-PGJ(2) is mediated by CRTH2, although the CRTH2 activation alone is insufficient for the underlying action.
引用
收藏
页码：89 / 93
页数：5
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