Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

被引：8

作者：

de Sousa Luis, Jose Alixandre ^{[1
,2
]}

Barbosa Filho, Jose Maria ^{[1
]}

Lira, Bruno Freitas ^{[1
]}

Medeiros, Isac Almeida ^{[1
]}

Soares Lima de Morais, Liana Clebia ^{[1
]}

dos Santos, Alexsandro Fernandes ^{[3
]}

de Oliveira, Cledualdo Soares ^{[3
]}

de Athayde-Filho, Petronio Filgueiras ^{[1
,3
]}

机构：

[1] Univ Fed Paraiba, Lab Tecnol Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil

[2] Univ Fed Campina Grande, Unidade Acad Saude, Ctr Educ & Saude, BR-58175000 Cuite, PB, Brazil

[3] Univ Fed Paraiba, Dept Quim, BR-58059000 Joao Pessoa, Paraiba, Brazil

来源：

MOLECULES | 2010年 / 15卷 / 01期

关键词：

hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones;

D O I：

10.3390/molecules15010128

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70-74%. The mass, infrared, H-1 and C-13-NMR spectra of representative products are discussed.

引用

页码：128 / 137

页数：10

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