Recent Advances in C-H Fluorination and Amination with N-Fluorobenzenesulfonimide

The nitrogen- and fluorine-containing molecules display multiple important bioactivities which are crucial compounds in medicinal chemistry. The strategy relies on the transition-metal-catalyzed C-H amination and fluorination has received much attention due to its atom- and step-economy, providing an alternative to the synthesis of many natural alkaloids and fluorides. N-Fluorobenzenesulfonimide (NFSI) consists of the fluoride atom and the nitrogen-containing functionality, it is frequently used in the reactions based on transition-metal-catalyzed C-H activation to construct both C-N and C-F bonds. In this mini-review, the recent research advances in the formation of C-N and C-F bonds through transition-metal-catalyzed C-H with NSFI are reviewed. The reaction scopes and mechanisms are discussed in details, and the limitations of current procedures and the prospects for the future are summarized.