Novel One-Pot Cyclization of the Blaise Reaction Intermediate and Arylglyoxals: The Synthesis of Substituted NH -Pyrroles

被引：12
|
作者：
Chen, Zhiwei [1 ,2 ]
Chen, Hao [1 ,2 ]
Yang, Xiaofeng [1 ,2 ]
Chang, Xiangqing [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Natl Engn Res Ctr Proc Dev Act Pharmaceut Ingredi, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipm, Minist Educ, Hangzhou 310014, Zhejiang, Peoples R China
来源：
SYNLETT | 2017年 / 28卷 / 12期
基金：
中国国家自然科学基金;
关键词：
pyrroles; Blaise reaction intermediate; arylglyoxals; Reformatsky reagent; chromeno; 4-hydroxy-1; H; -pyrrole; POLYSUBSTITUTED PYRROLES; FUNCTIONALIZED PYRROLES; 3-COMPONENT SYNTHESIS; DERIVATIVES; NITRILES; AMINES; CYCLOADDITION; ROSEOPHILIN; ALKALOIDS; ETHERS;
D O I：
10.1055/s-0036-1588168
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively to afford a wide variety of substituted NH-pyrroles in good yields.
引用
收藏
页码：1463 / 1466
页数：4
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