Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: Synthesis of Tetrahydropyridoindoles

被引：20

作者：

Jin, Xiao-Yang ^{[1
,2
]}

Xie, Li-Jun ^{[1
,2
]}

Cheng, Hou-Ping ^{[1
,2
]}

Liu, An-Di ^{[1
,2
]}

Li, Xue-Dong ^{[1
,2
]}

Wang, Dong ^{[1
]}

Cheng, Liang ^{[1
,2
]}

Liu, Li ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, CAS Key Lab Mol Recognit & Funct,BNLMS, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 14期

基金：

北京市自然科学基金; 中国国家自然科学基金; 国家重点研发计划;

关键词：

CARBOXYLIC-ACIDS; DIRECTING GROUP; STEREOSELECTIVE-SYNTHESIS; BOND FUNCTIONALIZATIONS; RECEPTOR ANTAGONISTS; CONJUGATE ADDITION; ACTIVATED ALKENES; TRICYCLIC INDOLES; ORGANIC-SYNTHESIS; WATER;

D O I：

10.1021/acs.joc.8b00229

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We disclose herein a Ru(II)-catalyzed decarboxylative and oxidative coupling of N-substituted indolyl carboxylic acids with broad substrate scope in an aqueous solution. This method provides a sustainable and efficient access to synthesize various indole-fused cyclohexanyl acetic acids under mild conditions.

引用

页码：7514 / 7522

页数：9

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