Synthesis and anticonvulsant screening of 2-(substituted aryl)-3-(4H, 1,2,4-triazol-4-yl), 1,3-thiazolidin-4-ones

被引：0
|
作者：
Siddiqui, Nadeem [1 ]
Deepanjali [1 ]
Arshad, Md. Faiz [1 ]
Rana, Arpana [1 ]
机构：
[1] Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 16卷 / 04期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-(substituted aryl)-3-(4H-1,2,4-triazol-4-yl)-1,3-thiazolidin-4-ones (2a-p) were synthesized and screened for their anticonvulsant profile and neurotoxicity. The structures of the compounds have been elucidated on the basis of their elemental and spectral data. The compounds 2d and 2p were potent anti MES agents showing no sign of neurological deficit whereas compounds 2a, 2b and 2c were also potent but neurotoxic.
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页码：403 / 404
页数：2
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