Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology

被引：15
|
作者：
Rabjohns, Emily M. [1 ]
Hurst, Katlyn [2 ]
Ghosh, Arin [2 ]
Cuellar, Maria C. [3 ]
Rampersad, Rishi R. [1 ]
Tarrant, Teresa K. [1 ]
机构：
[1] Duke Univ, Dept Med, Div Rheumatol & Immunol, DUMC 3874,200 Trent Dr, Durham, NC 27710 USA
[2] Duke Univ, Durham, NC USA
[3] Hosp Salvador, Div Rheumatol, Dept Med, Santiago, Chile
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2021年 / 21卷 / 04期
关键词：
Paget's disease of bone; Osteoimmunology; Osteoclast; Chemokines; Chemokine receptor; Optineurin; Bisphosphonate;
D O I：
10.1007/s11882-021-01001-2
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Purpose of ReviewThe purpose of this review is to recognize clinical features of Paget's disease of bone and to describe how the osteoclast, a myeloid-derived cell responsible for bone resorption, contributes to the disease.Recent FindingsRecent studies have identified several variants in SQSTM1, OPTN, and other genes that may predispose individuals to Paget's disease of bone; studies of these genes and their protein products have elucidated new roles for these proteins in bone physiology.SummaryUnderstanding the pathologic mechanisms in the Pagetic osteoclast may lead to the identification of future treatment targets for other inflammatory and autoimmune diseases characterized by abnormal bone erosion and/or osteoclast activation.
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页数：12
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