Sesquiterpene isocyanides, isothiocyanates, thiocyanates, and formamides from the Thai sponge Halichondria sp.

被引：15
|
作者：
Prawat, Hunsa [1 ]
Mahidol, Chulabhorn [1 ,2 ]
Kaweetripob, Wirongrong [1 ]
Prachyawarakorn, Vilailak [1 ]
Tuntiwachwuttikul, Pittaya [3 ]
Ruchirawat, Somsak [1 ,2 ]
机构：
[1] Chulabhorn Res Inst, Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand
[2] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol EHT, Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand
[3] Phuket Rajabhat Univ, Fac Sci & Technol, Lab Nat Prod Chem, Phuket 83000, Thailand
来源：
TETRAHEDRON | 2016年 / 72卷 / 29期
关键词：
Sesquiterpenes; Isocyanides; Isothiocyanates; Thiocyanates; Formamides; Thai sponge; Halichondria; NITROGENOUS SESQUITERPENES; AXINYSSA-APLYSINOIDES; TERPENOID ISOCYANIDE; COLORIMETRIC ASSAY; COOCCURRENCE; METABOLITES;
D O I：
10.1016/j.tet.2016.05.060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nine new nitrogenous sesquiterpenes (1-9) were isolated together with 11 known compounds (10-20) from the Thai marine sponge Halichondria sp. The structures of the isolated compounds were determined on the basis of extensive NMR studies and high-resolution MS measurements as well as comparison with literature data. Sixteen of these metabolites were evaluated for cytotoxic activity against six tumor cell lines. (C) 2016 Published by Elsevier Ltd.
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收藏
页码：4222 / 4229
页数：8
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