Multigram Four-Step Synthesis of 1,4,7-Triazacyclononanes with 2Ra/Rb N-Functionalization Pattern by Starting from Diethylenetriamine

被引：7

作者：

Gros, Guillaume ^{[1
]}

Hasserodt, Jens ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, Lab Chim, CNRS, UMR 5182, F-69364 Lyon, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 01期

关键词：

Macrocycles; Chemoselectivity; Tridentate ligands; Amination; Alkylation; OXYGEN INSERTION; COMPLEXES; LIGANDS; IRON(III); MODEL;

D O I：

10.1002/ejoc.201402821

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyazamacrocycles and their derivatives are appreciated for the strength of their corresponding metal complexes. 1,4,7-Triazacyclononane (TACN) derivatives have been employed in an ever increasing number of applications. To this day, all synthetic routes to TACN derivatives that have identical or differing substituents require the initial preparation of unprotected TACN. Herein, we report the four-step synthesis of TACN derivatives that have a 2R(a)/RbN-functionalization pattern by starting from diethylenetriamine and employing an organic template strategy.

引用

页码：183 / 187

页数：5