Iron-Catalyzed Coupling of Propargyl Bromides and Alkyl Grignard Reagents

被引：23
|
作者：
Domingo-Legarda, Pablo [1 ]
Soler-Yanes, Rita [1 ]
Teresa Quiros-Lopez, M. [1 ]
Bunuel, Elena [1 ]
Cardenas, Diego J. [1 ]
机构：
[1] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Campus Cantoblanco, E-28049 Madrid, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 35期
关键词：
C-C coupling; Iron; Grignard reaction; Radical reactions; Homogeneous catalysis; MAGNETIC CIRCULAR-DICHROISM; FUNCTIONAL THEORY APPROACH; NICKEL PINCER COMPLEX; CROSS-COUPLINGS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; TRISUBSTITUTED ALLENES; ELECTRONIC-STRUCTURE; ASYMMETRIC-SYNTHESIS; ALPHA-ALLENOLS;
D O I：
10.1002/ejoc.201800849
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An iron-catalyzed Kumada-type cross-coupling reaction of propargyl halides with alkylmagnesium reagents is described. The reaction is fast, takes place in smooth conditions, tolerates several functional groups that would be able to react with the Grignard reagent, and may afford either allene or propargyl coupling derivatives. Factors involved in the observed regioselectivity have been studied.
引用
收藏
页码：4900 / 4904
页数：5
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