Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection

被引：2
|
作者：
Bresser, Paul
Cornelissen, Marion I.
van der Bij, Wim
van Noesel, Carel J. M.
Timens, Wim
机构：
[1] Univ Amsterdam, Acad Med Ctr F5 144, Dept Pulm, NL-1100 DE Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1100 DE Amsterdam, Netherlands
[3] Univ Groningen, Med Ctr, Dept Pulm, Groningen, Netherlands
[4] Univ Groningen, Med Ctr, Dept Pathol, Groningen, Netherlands
来源：
RESPIRATORY MEDICINE | 2007年 / 101卷 / 04期
关键词：
human herpes virus-8; idiopathic pulmonary; arterial hypertension; pulmonary hypertension; infection; pathogenesis;
D O I：
10.1016/j.rmed.2006.08.015
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV-8 tatency-associated nuclear antigen 1 (LANA-1) was demonstrated. Using two nested polymerase chain reactions (PCR) to amplify part of the open reading frame (ORF) 65 and ORF 73, we failed to detect HHV-8 DNA in all samples studied. These results argue strongly against a role for HHV-8 in the pathogenesis of iPAH. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：854 / 856
页数：3
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