Antiplasmodial and Cytotoxic Activity of Phloroglucinol Derivatives from Hypericum erectum Thunb

被引：17
|
作者：
Moon, Hyung-In [1 ,2 ]
机构：
[1] Dongguk Univ, Coll Korean Med, Cardiovasc Med Res Ctr, Gyeong Ju 780714, South Korea
[2] Wonkwang Univ, Sanbon Med Ctr, Inam Neurosci Res Ctr, Kyonggi Do 435040, South Korea
来源：
PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 06期
关键词：
Hypericum erectum; antiplasmodial activity; Plasmodium falciparum; otogirin; otogirone; erectquione A; erectquione B; erectquione C; MALARIA;
D O I：
10.1002/ptr.3104
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The chloroform extracts of whole plants of Hypericum erectum were investigated for antiplasmodial activity against chloroquine-sensitive strains of Plasmodium falciparum. Five phloroglucinol derivatives, otogirin (1), otogirone (2), erectquione A (3), erectquione B (4), and erectquione C (5) were isolated from the whole plants of H. erectum. Also, five compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 2, 4 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 5.6 and 7.2 mu M. This compound showed no significant cytotoxicity (IC(50) > 150 mu M) evaluated using SK-OV-3 cancer cell line cells. Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码：941 / 944
页数：4
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