Correlation Between 18F-FDG-uptake and In Vitro Chemosensitivity of Cisplatin in Head and Neck Cancer

被引：0
|
作者：
Suzuki, Hidenori [1 ]
Nishio, Masami [2 ]
Hanai, Nobuhiro [1 ]
Hirakawa, Hitoshi [1 ]
Tamaki, Tsuneo [3 ]
Hasegawa, Yasuhisa [1 ]
机构：
[1] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Nagoya, Aichi 4648681, Japan
[2] Nagoya PET Imaging Ctr, Dept Radiol, Nagoya, Aichi, Japan
[3] East Nagoya Imaging Diag, Nagoya, Aichi, Japan
来源：
ANTICANCER RESEARCH | 2015年 / 35卷 / 02期
关键词：
Head and neck cancer; overall survival; F-18-FDG-PET/CT; SUVmax; inhibition index cisplatin; DRUG RESPONSE ASSAY; SQUAMOUS-CELL-CARCINOMA; STANDARDIZED UPTAKE VALUE; PROGNOSTIC VALUE; FDG-PET; DEFINITIVE CHEMORADIOTHERAPY; ESOPHAGEAL CANCER; LUNG-CANCER; PREDICTION; SURVIVAL;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: High [F-18]-2-fluorodeoxyglucose (F-18-FDG) -uptake of primary tumor, assessed by pretreatment positron emission tomography combined computed tomography (PET/CT), has indicated poor overall survival (OS) in head and neck cancer (HNC). We investigated the correlation between F-18-FDG-uptake and in vitro chemosensitivity of cisplatin using histoculture drug response assay in HNC. Patients and Methods: Twenty-eight patients were evaluated. The maximum standardized uptake value (SUVmax) and inhibition index (I. I.) cisplatin were calculated as F-18-FDG-uptake and in vitro chemosensitivity of cisplatin. Results: Each SUVmax >= 10.5 or I. I. cisplatin <50 could significantly differentiate shorter survival group by OS analyses. I. I. cisplatin of patients with SUVmax = 10.5 was significantly greater. In 19 patients with SUVmax = 10.5, those who received treatment with cisplatin-based chemotherapy exhibited a significant correlation with longer OS. Conclusion: Cisplatin hasthe potential to improve OS for HNC patients that were predicted as shorter OS by(18)F-FDG-PET/CT.
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收藏
页码：1009 / 1016
页数：8
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