PGC-1: The Energetic Regulator in Cardiac Metabolism

被引：104
|
作者：
Di, Wencheng [1 ]
Lv, Jianjun [2 ,3 ]
Jiang, Shuai [4 ]
Lu, Chenxi [2 ]
Yang, Zhi [3 ]
Ma, Zhiqiang [5 ]
Hu, Wei [3 ]
Yang, Yang [2 ,3 ]
Xu, Biao [1 ]
机构：
[1] Nanjing Univ, Dept Cardiol, Med Sch, Affiliated Drum Tower Hosp, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China
[2] Northwest Univ, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China
[3] Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
[4] Fourth Mil Med Univ, Dept Aerosp Med, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
[5] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
来源：
CURRENT ISSUES IN MOLECULAR BIOLOGY | 2018年 / 28卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
PROLIFERATOR-ACTIVATED RECEPTOR; ALPHA ERR-ALPHA; TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; ATTENUATES MITOCHONDRIAL DYSFUNCTION; NUCLEAR RESPIRATORY FACTOR-1; ACUTE MYOCARDIAL-INFARCTION; FATTY-ACID OXIDATION; SKELETAL-MUSCLE; PROTEIN-KINASE; HEART-FAILURE;
D O I：
10.21775/cimb.028.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1s (PGC-1s) can induce the expression of several downstream genes that play pivotal roles in the regulation of mitochondrial biogenesis and metabolism in the heart. Moreover, PGC-1 signaling pathways have also been reported to play a critical role in cardioprotection. Given the significance of PGC-1 coactivators, we summarize the current literature on the molecular mechanisms and roles of PGC-1s in cardiac metabolism. Thus, in this review, we first introduce the basic knowledge regarding PGC-1 signaling pathways. We then discuss their roles in heart metabolism. Moreover, we describe several significant treatments that target the PGC-1 signaling pathway. This review presents the significant roles of PGC-1s in cardiac metabolism and may contribute to the promotion of PGC-1 signaling pathway as a novel therapeutic target.
引用
收藏
页码：29 / 46
页数：18
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