Update on Legionnaires' disease: pathogenesis, epidemiology, detection and control

被引:50
|
作者
Hilbi, Hubert [5 ]
Jarraud, Sophie [4 ]
Hartland, Elizabeth [3 ]
Buchrieser, Carmen [1 ,2 ]
机构
[1] Inst Pasteur, Paris, France
[2] CNRS, URA 2171, Paris, France
[3] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
[4] Univ Lyon, INSERM, Fac Med, Ctr Natl Reference Legionella,U851,IFR 128, Lyon, France
[5] Univ Zurich, Inst Mol Life Sci, CH-8057 Zurich, Switzerland
基金
英国医学研究理事会; 澳大利亚研究理事会; 瑞士国家科学基金会;
关键词
NUCLEOTIDE EXCHANGE FACTOR; LEGIONELLA-PNEUMOPHILA; TRIPHOSPHATE DIPHOSPHOHYDROLASE; RESPIRATORY SAMPLES; SEQUENCE TYPES; FRESH-WATER; DIFFERENTIATION; TRANSMISSION; CSRA; REPLICATION;
D O I
10.1111/j.1365-2958.2010.07086.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
P>Legionellosis or Legionnaires' disease is an emerging and often-fatal form of pneumonia that is most severe in elderly and immunocompromised people, an ever-increasing risk group for infection. In recent years, the genomics of Legionella spp. has significantly increased our knowledge of the pathogenesis of this disease by providing new insights into the evolution and genetic and physiological basis of Legionella-host interactions. The seventh international conference on Legionella, Legionella 2009, illustrated many recent conceptual advances in epidemiology, pathogenesis and ecology. Experts in different fields presented new findings on basic mechanisms of pathogen-host interactions and bacterial evolution, as well as the clinical management and environmental prevalence and persistence of Legionella. The presentations revealed remarkable facts about the genetic and metabolic basis of the intracellular lifestyle of Legionella and reported on its striking ability to manipulate host cell processes by molecular mimicry. Together, these investigations will lead to new approaches for the treatment and prevention of Legionnaires' disease.
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页码:1 / 11
页数:11
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