Natural convection heat transfer within nanofluid porous cavities with local heaters occurs in different engineering applications. Therefore, analysis of nanofluid flow and heat transfer patterns in such systems has a significant value for development of industry. In the present study, free convection of nanofluid in a tilted porous cavity with a local isothermal heater has been investigated numerically. Governing equations with corresponding initial and boundary conditions formulated using the Darcy-Boussinesq model and local thermal non-equilibrium approach have been solved by the finite difference method under the effects of Brownian diffusion and thermophoresis. Effects of heater location (delta = 0.1-0.3) and dimensionless length (D = 0.2-0.8) as well as cavity inclination angle gamma = 0-pi/2) and interphase heat transfer coefficient (H = 10-1000) on nanofluid flow and heat transfer have been studied for the following values of other governing parameters: Rayleigh number (Ra = 10(5)), Prandtl number (Pr = 6.82), Darcy number (Da = 10(-3)), porosity of porous medium (epsilon = 0.5), buoyancy ratio parameter (Nr = 1), Brownian diffusion parameter (Nb = 10(-6)), thermophoresis parameter (Nt = 10(-6)), Lewis number (Le = 1000), thermal diffusivity ratio (Gamma = 649.7) and heat capacitance ratio xi = 3.4). It has been found the heat transfer enhancement and convective flow attenuation when the distance between the heater and the cold vertical wall reduces. (C) 2018 Published by Elsevier B.V.