Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

被引：63
|
作者：
Ciudin, Andreea [1 ,2 ]
Espinosa, Ana [3 ]
Simo-Servat, Olga [1 ,2 ]
Ruiz, Agustin [3 ]
Alegret, Montserrat [3 ]
Hernandez, Cristina [1 ,2 ]
Boada, Merce [3 ]
Simo, Rafael [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona VHIR UAB, Inst Recerca Vall dHebron, Barcelona, Spain
[2] CIBER Diabet & Enfermedades Metabol Asociadas, Inst Salud Carlos 3, Madrid, Spain
[3] Fundacio ACE, Barcelona Alzheimer Treatment & Res Ctr, Barcelona, Spain
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 08期
关键词：
FOLLOW-UP; ALZHEIMERS-DISEASE; PEOPLE; MELLITUS;
D O I：
10.1016/j.jdiacomp.2017.04.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02).T2D and APOE epsilon 4 allele were independent risk factors for developing dementia. Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1272 / 1274
页数：3
相关论文
共 50 条
  • [1] Type 2 Diabetes Is an Independent Risk Factor for Dementia Conversion in Mild Cognitive Impairment Patients
    Ciudin, Andreea
    Simo-Servat, Olga
    Hernandez Pascual, Cristina
    Boada, Merce
    Simo, Rafael
    DIABETES, 2016, 65 : A386 - A386
  • [2] Type 2 diabetes is an independent risk factor for dementia conversion in mild cognitive impairment patients
    Ciudin, A.
    Espinosa, A.
    Ruiz, A.
    Alegret, M.
    Hernandez, C.
    Boada, M.
    Simo, R.
    DIABETOLOGIA, 2013, 56 : S523 - S523
  • [3] Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment
    Albai, Oana
    Frandes, Mirela
    Timar, Romulus
    Roman, Deiana
    Timar, Bogdan
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2019, 15 : 167 - 175
  • [4] Type 2 diabetes and risk of cognitive impairment and dementia
    Rachel A. Whitmer
    Current Neurology and Neuroscience Reports, 2007, 7 : 373 - 380
  • [5] Type 2 diabetes and risk of cognitive impairment and dementia
    Whitmer, Rachel A.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2007, 7 (05) : 373 - 380
  • [6] Conversion of amnestic Mild Cognitive Impairment to Dementia of Alzheimer type is independent to memory deterioration
    Rozzini, Luca
    Chilovi, Barbara Vicini
    Conti, Marta
    Bertoletti, Erik
    Delriol, Ilenia
    Trabucchi, Marco
    Padovani, Alessandro
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2007, 22 (12) : 1217 - 1222
  • [7] Lower free triiodothyronine is a risk factor of mild cognitive impairment in type 2 diabetes patients with euthyroidism
    Zhang, H.
    Zhu, W.
    Wang, S.
    DIABETOLOGIA, 2020, 63 (SUPPL 1) : S456 - S456
  • [8] Incidence of dementia and mild cognitive impairment in elders with type 2 diabetes
    Maria Salinas, Rosa
    Luisa Sosa, Ana
    Hiriart, Marcia
    Acosta, Isaac
    INTERNATIONAL PSYCHOGERIATRICS, 2013, 25 : S138 - S138
  • [9] Diabetes A risk factor for cognitive impairment and dementia?
    Singh-Manoux, Archana
    Schmidt, Reinhold
    NEUROLOGY, 2015, 84 (23) : 2300 - 2301
  • [10] Conversion of mild cognitive impairment to dementia
    Velasquez-Perez, Leora
    Guerrero-Camacho, Jorge
    Rodriguez-Agudelo, Yaneth
    Alonso-Vilatela, Maria Elisa
    Yescas-Gomez, Petra
    REVISTA ECUATORIANA DE NEUROLOGIA, 2008, 17 (1-3): : 25 - 32
12345