What role does dopamine really play in tobacco addiction?

被引：2
|
作者：
Chiamulera, Cristiano [1 ]
West, Robert J. [2 ]
机构：
[1] Univ Verona, Pharmacol Sect, Dept Diagnost & Publ Hlth, Verona, Italy
[2] UCL, Dept Behav Sci & Hlth, London, England
来源：
ADDICTION | 2018年 / 113卷 / 08期
基金：
英国医学研究理事会;
关键词：
Addiction; dopamine; nicotine; smoking; smoking cessation; tobacco; MESOLIMBIC DOPAMINE; NICOTINE; MECHANISMS;
D O I：
10.1111/add.14235
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
A prevailing narrative explaining tobacco addiction is that uptake of nicotine in the brain causes dopamine release in the nucleus accumbens which rewards the behaviour that led to it. However, evidence suggests that in this and other addictive disorders a more nuanced and multi-level model is required that recognizes how dopamine interacts with other parts of a complex system to maintain maladaptive behaviour patterns.
引用
收藏
页码：1379 / 1380
页数：2
相关论文
共 50 条
  • [1] DOES DOPAMINE PLAY A ROLE IN SCHIZOPHRENIA
    CARLSSON, A
    PSYCHOLOGICAL MEDICINE, 1977, 7 (04) : 583 - 597
  • [2] What Role Does Striatal Dopamine Play in Goal-directed Action?
    Hart, Genevra
    Burton, Thomas J.
    Balleine, Bernard W.
    NEUROSCIENCE, 2024, 546 : 20 - 32
  • [3] Alexithymia and addiction behaviours: does trauma play a role?
    Caretti, V.
    EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, 2013, 4
  • [4] Does helicity really play a role in supercell longevity?
    Droegemeier, KK
    Bassett, GM
    Lilly, DK
    18TH CONFERENCE ON SEVERE LOCAL STORMS, 1996, : 205 - 209
  • [5] What role does tobacco smoking play in multiple sclerosis disability and mortality? A review of the evidence
    Weston, Mikail
    Constantinescu, Cris S.
    NEURODEGENERATIVE DISEASE MANAGEMENT, 2015, 5 (01) : 19 - 25
  • [6] Does reverse transport of dopamine play a role in autism?
    Emanuele, Enzo
    EBIOMEDICINE, 2015, 2 (02): : 98 - +
  • [7] What Role does Chlamydia trachomatis play?
    Rusz, Andras
    Pilatz, Adrian
    Wagenlehner, Florian
    Weidner, Wolfgang
    AKTUELLE UROLOGIE, 2012, 43 (01) : 11 - 12
  • [8] Endophthalmitis: what role does vitrectomy play?
    Rocha De Sousa, A.
    Mendonca, C.
    Alves-Faria, P.
    Gouveia, P.
    Faicao, M.
    Falcao-Reis, F.
    ACTA OPHTHALMOLOGICA, 2017, 95
  • [9] Does lactose maldigestion really play a role in the irritable bowel?
    Tolliver, BA
    Jackson, MS
    Jackson, KL
    Barnett, ED
    Chastang, JF
    DiPalma, JA
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 1996, 23 (01) : 15 - 17
  • [10] Faith: what role does it play in medicine?
    Kermode-Scott, B
    CANADIAN FAMILY PHYSICIAN, 1999, 45 : 2540 - 2541
12345