The tumor suppressor protein p16INK4a

被引：268
|
作者：
Serrano, M [1 ]
机构：
[1] CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain
来源：
EXPERIMENTAL CELL RESEARCH | 1997年 / 237卷 / 01期
关键词：
D O I：
10.1006/excr.1997.3824
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The tumor suppressor protein p16(INK4a) (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16(INK4a) gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16(INK4a) is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16(INK4a) are starting to be characterized. (C) 1997 Academic Press.
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页码：7 / 13
页数：7
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