Salvage High-dose-rate Interstitial Brachytherapy for Pelvic Recurrent Cervical Carcinoma After Hysterectomy

被引：5
|
作者：
Murakami, Naoya [1 ]
Kato, Tomoyasu [2 ]
Miyamoto, Yuichiro [3 ]
Nakamura, Satoshi [1 ]
Wakita, Akihisa [1 ]
Okamoto, Hiroyuki [1 ]
Tsuchida, Keisuke [1 ]
Kashihara, Tairo [1 ]
Kobayashi, Kazuma [1 ]
Harada, Ken [1 ]
Kitaguchi, Mayuka [1 ]
Sekii, Shuhei [1 ]
Takahashi, Kana [1 ]
Umezawa, Rei [1 ]
Inaba, Koji [1 ]
Ito, Yoshinori [1 ]
Igaki, Hiroshi [1 ]
Itami, Jun [1 ]
机构：
[1] Natl Canc Ctr, Dept Radiat Oncol, 5-1-1 Tsukiji, Tokyo 1040045, Japan
[2] Natl Canc Ctr, Dept Gynecol Oncol, 5-1-1 Tsukiji, Tokyo 1040045, Japan
[3] Saitama Canc Ctr, Dept Gynecol, Saitama, Japan
来源：
ANTICANCER RESEARCH | 2016年 / 36卷 / 05期
关键词：
Salvage interstitial brachytherapy; high-dose-rate interstitial brachytherapy; uterine cervical cancer; post hysterectomy relapse; MODULATED RADIATION-THERAPY; GYNECOLOGIC-ONCOLOGY-GROUP; CLINICAL TARGET VOLUME; RADICAL HYSTERECTOMY; COMPUTED-TOMOGRAPHY; CANCER; RADIOTHERAPY; STAGE; MALIGNANCIES; EXENTERATION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The aim of this study was to report the clinical results of salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with cervical cancer with pelvic recurrence after hysterectomy. Patients and Methods: When there was no indication for total pelvic extenteration (TPE) and the tumor depth was more than 5 mm of invasion in the paracolpium, salvage HDR-ISBT was applied. Results: A total of 26 patients were included in this study. The median number of fractions and dose per fraction of HDR-ISBT were 5 (range=3-20 fractions) and 6 Gy (range=2.5-6 Gy), respectively. Three-year local control, progression-free survival, and overall survival were 51.1%, 34.4% and 57.1%, respectively. Combination of external-beam radiation therapy, clinical target volume D90 greater than 65 Gy, and dose per fraction greater than 5 Gy were associated with favorable local control. Conclusion: For patients with recurrent cervical cancer post hysterectomy who are not candidates for TPE, salvage HDR-ISBT is a possible curative treatment modality.
引用
收藏
页码：2413 / 2421
页数：9
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