Construction of Sulfonyl Phthalides via Copper-Catalyzed Oxysulfonylation of 2-Vinylbenzoic Acids with Sodium Sulfinates

被引：34

作者：

Xiong, Yan-Shi ^{[1
]}

Zhang, Bin ^{[1
]}

Yu, Yang ^{[1
]}

Weng, Jiang ^{[1
]}

Lu, Gui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 21期

关键词：

DIRECTED ASYMMETRIC HYDROGENATION; C-H SULFONYLATION; ACTIVATION; PHOTOREDOX; ALKENES; ACCESS; DIFUNCTIONALIZATION; CYCLIZATION; LACTONES; STRATEGY;

D O I：

10.1021/acs.joc.9b01646

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed difunctionalization of 2-vinyl-benzoic acids with sodium sulfinates to construct substituted lactones has been realized. This protocol employs inexpensive CuCl2 as the catalyst, di-tert-butyl peroxide or O-2 as the terminal oxidant, and readily available sodium sulfinates as sulfonylation reagents. High functional group tolerance and excellent yields were demonstrated by the efficient preparation of a wide range of gamma-sulfonylated phthalides.

引用

页码：13465 / 13472

页数：8

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