Piquing our interest: Insights into the role of PEAK3 in signaling and disease

被引：2

作者：

Paul, Michael D. ^{[1
]}

Torosyan, Hayarpi ^{[1
]}

Jura, Natalia ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

来源：

SCIENCE SIGNALING | 2022年 / 15卷 / 722期

关键词：

D O I：

10.1126/scisignal.abm9396

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudokinases are critical signaling hubs that are increasingly appreciated as important disease targets. In this issue of Science Signaling, Hou et al. bring new insights into the signaling mechanisms of the pseudokinase PEAK3 by characterizing its epidermal growth factor-dependent interactome and demonstrating oncogenic effects of PEAK3 overexpression.

引用

页数：3

共 50 条

[1] Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family
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[2] Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3
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