Effect of Vitamin E on the Content and Polypeptide Composition of Glial Fibrillary Acidic Protein from the Rat Brain under Conditions of Aluminum Chloride Intoxication

被引：0

作者：

Nedzvetsky, V. S. ^{[1
]}

Tikhomirov, A. A. ^{[1
]}

Nerush, P. A. ^{[2
]}

机构：

[1] Dnepropetrovsk Natl Univ, Dnepropetrovsk, Ukraine

[2] Minist Publ Hlth Ukraine, Dnepropetrovsk State Med Acad, Dnepropetrovsk, Ukraine

来源：

NEUROPHYSIOLOGY | 2005年 / 37卷 / 01期

关键词：

astroglia; intermediate filaments; glial fibrillary acidic protein (GFAP); aluminum chloride; vitamin E;

D O I：

10.1007/s11062-005-0039-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effects of isolated and combined chronic (21 days) introductions of aluminum chloride and vitamin E (alpha-tocopherol) on the polypeptide composition and content of glial fibrillary acidic protein (GFAP) in different brain structures of rats. Injections of AlCl3 solution (12 mg/kg, i.p., daily) caused the appearance of low-molecular (47 to 38 kdalton) polypeptides and an increase in the content of GFAP in cytoskeletal fractions to 160 to 220%, as compared with the control. Introduction of vitamin E within the same interval provided significant normalization of the GFAP content in the brain of animals injected with AlCl3 and to a considerable extent prevented the appearance of degraded polypeptides in the GFAP composition. We discuss the prospects of using vitamin E as an antioxidant for the correction of Al3+-induced pathological processes in the CNS.

引用

页码：13 / 18

页数：6

共 8 条

[1] Effect of Vitamin E on the Content and Polypeptide Composition of Glial Fibrillary Acidic Protein from the Rat Brain under Conditions of Aluminum Chloride Intoxication
V. S. Nedzvetsky
A. A. Tikhomirov
P. A. Nerush
Neurophysiology, 2005, 37 : 13 - 18
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L. A. Dzyak
T. I. Duka
A. L. Drozdov
V. I. Chernaya
Neurophysiology, 1999, 31 : 290 - 291
[3] Glial fibrillary acidic protein in rat brain structures under conditions of training for a passive defensive habit
Dzyak, LA
Duka, TI
Drozdov, AL
Chernaya, VI
NEUROPHYSIOLOGY, 1999, 31 (04) : 290 - 291
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DAHL, D
BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 420 (01) : 142 - 154
[5] DISTRIBUTION OF GLIAL FIBRILLARY ACIDIC PROTEIN AND FIBRONECTIN IN PRIMARY ASTROGLIAL CULTURES FROM RAT-BRAIN
STIEG, PE
KIMELBERG, HK
MAZURKIEWICZ, JE
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[6] GLIAL FIBRILLARY ACIDIC PROTEIN IN PRIMARY ASTROGLIAL CELL-CULTURES DERIVED FROM NEWBORN RAT-BRAIN
BOCK, E
MOLLER, M
NISSEN, C
SENSENBRENNER, M
FEBS LETTERS, 1977, 83 (02) : 207 - 211
[7] BIOCHEMICAL AND ULTRASTRUCTURAL STUDIES OF CULTURED RAT ASTROGLIAL CELLS - EFFECT OF BRAIN EXTRACT AND DIBUTYRYL-CYCLIC-AMP ON GLIAL FIBRILLARY ACIDIC PROTEIN AND GLIAL FILAMENTS
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DIFFERENTIATION, 1980, 17 (01) : 51 - 61
[8] Effect of L-Tryptophan on the Content of Free Amino Acids and Biogenic Amines in Rat Brain under Conditions of Subchronic Phenobarbital Intoxication
Yu. E. Razvodovskii
E. M. Doroshenko
Pharmaceutical Chemistry Journal, 2003, 37 (1) : 4 - 5

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