Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

被引：170

作者：

Kawabe, Hiroshi ^{[1
]}

Neeb, Antje ^{[1
]}

Dimova, Kalina ^{[1
,2
,3
]}

Young, Samuel M., Jr. ^{[4
]}

Takeda, Michiko ^{[1
]}

Katsurabayashi, Shutaro ^{[4
]}

Mitkovski, Miso ^{[5
]}

Malakhova, Oxana A. ^{[6
]}

Zhang, Dong-Er ^{[6
,7
,8
]}

Ulmilkawa, Masato ^{[9
]}

Kariya, Ken-ichi ^{[9
]}

Goebbels, Sandra ^{[10
]}

Nave, Klaus-Armin ^{[10
]}

Rosenmund, Christian ^{[4
]}

Jahn, Olaf ^{[2
,3
]}

Rhee, JeongSeop ^{[1
,4
]}

Brose, Nils ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany

[2] Max Planck Inst Expt Med, Prote Grp, D-37075 Gottingen, Germany

[3] DFG CMPB, D-37075 Gottingen, Germany

[4] Max Planck Inst Biophys Chem, Dept Membrane Biophys, D-37077 Gottingen, Germany

[5] Max Planck Inst Expt Med, Imaging Facil, D-37075 Gottingen, Germany

[6] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[7] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Div Biol, La Jolla, CA 92093 USA

[9] Univ Ryukyus, Div Cell Biol, Grad Sch Med, Nishihara, Okinawa 9030215, Japan

[10] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

来源：

NEURON | 2010年 / 65卷 / 03期

基金：

美国国家卫生研究院; 日本学术振兴会;

关键词：

NUCLEOTIDE EXCHANGE FACTOR; SYNAPSE ELIMINATION; HIPPOCAMPAL-NEURONS; PUTATIVE EFFECTOR; PYRAMIDAL NEURONS; ANGELMAN SYNDROME; CORTICAL-NEURONS; PROTEIN-KINASE; WW DOMAINS; PHOSPHORYLATION;

D O I：

10.1016/j.neuron.2010.01.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nedd4-1 is a "neuronal precursor cell expressed and developmentally downregulated protein" and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4-1-deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity of Rap2 effector kinases of the TNIK family and promotes dendrite growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons.

引用

页码：358 / 372

页数：15

共 50 条

[1] Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
Kawabe, H.
Neeb, A.
Dimova, K.
Young, S. M., Jr.
Takeda, M.
Katsurabayashi, S.
Mitkovski, M.
Malakhova, O. A.
Zhang, D. E.
Umikawa, M.
Kariya, K.
Goebbels, S.
Nave, K. A.
Rosenmund, C.
Jahn, O.
Rhee, J.
Brose, N.
NEUROFORUM, 2010, 16 (02): : 193 - 195
[2] Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development
Kawabe, Hiroshi
Neeb, Antje
Dimova, Kalina
Young, Samuel M., Jr.
Takeda, Michiko
Katsurabayashi, Shutaro
Mitkovski, Miso
Malakhova, Oxana A.
Zhang, Dong-Er
Umikawa, Masato
Kariya, Ken-ichi
Goebbels, Sandra
Nave, Klaus-Armin
Rosenmund, Christian
Jahn, Olaf
Rhee, JeongSeop
Brose, Nils
NEUROSCIENCE RESEARCH, 2010, 68 : E58 - E58
[3] Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1
Wang, Lei
Zhu, Bingxin
Wang, Shiquan
Wu, Yuxuan
Zhan, Wenjian
Xie, Shao
Shi, Hengliang
Yu, Rutong
ONCOLOGY REPORTS, 2017, 37 (05) : 2565 - 2574
[4] The ubiquitin E3 ligase Nedd4-1 controls neurite development
Kawabe, Hiroshi
Brose, Nils
CELL CYCLE, 2010, 9 (13) : 2477 - 2478
[5] The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
Fouladkou, Fatemeh
Landry, Tamara
Kawabe, Hiroshi
Neeb, Antje
Lu, Chen
Brose, Nils
Stambolic, Vuk
Rotin, Daniela
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (25) : 8585 - 8590
[6] Regulation of EGFR signaling by the E3 ubiquitin ligase Nedd4-1
Lin, Qiong
Wang, Jian
Childress, Chandra
Sudol, Marius
Carey, David J.
Yang, Wannian
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2010, 26 : S72 - S72
[7] The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1
Fouladkou, Fatemeh
Lu, Chen
Jiang, Chong
Zhou, Limei
She, Yimin
Walls, Jonathon R.
Kawabe, Hiroshi
Brose, Nils
Henkelman, R. M.
Huang, Annie
Bruneau, Benoit G.
Rotin, Daniela
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (09) : 6770 - 6780
[8] NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
Wang, Xinjiang
Trotman, Lloyd C.
Koppie, Theresa
Alimonti, Andrea
Chen, Zhenbang
Gao, Zhonghua
Wang, Junru
Erdjument-Bromage, Hediye
Tempst, Paul
Cordon-Cardo, Carlos
Pandolfi, Pier Paolo
Jiang, Xuejun
CELL, 2007, 128 (01) : 129 - 139
[9] Ubiquitin-dependent regulation of AKT by NEDD4-1
Wang, Xinjiang
Fan, Chuan-Dong
Lum, Michelle A.
Xu, Chao
Black, Jennifer D.
CANCER RESEARCH, 2013, 73 (08)
[10] SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization
Zhou, Weihua
Xu, Jie
Zhao, Yongchao
Sun, Yi
ONCOTARGET, 2014, 5 (16) : 6746 - 6755

← 1 2 3 4 5 →