Epstein-Barr Virus-associated Intracranial Leiomyosarcoma in an HIV-positive Adolescent

被引：24
|
作者：
Gupta, Sweta [1 ]
Havens, Peter L. [2 ]
Southern, James F. [3 ]
Firat, Selim Y. [4 ]
Jogal, Sachin S. [1 ]
机构：
[1] Childrens Hosp Wisconsin, Dept Pediat Hematol Oncol, Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] Childrens Hosp Wisconsin, Dept Infect Dis, Med Coll Wisconsin, Milwaukee, WI 53226 USA
[3] Childrens Hosp Wisconsin, Dept Pathol, Med Coll Wisconsin, Milwaukee, WI 53226 USA
[4] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 04期
关键词：
brain; leiomyosarcoma; human immunodeficiency virus; Epstein-Barr virus; HUMAN-IMMUNODEFICIENCY-VIRUS; SOFT-TISSUE SARCOMAS; SMOOTH-MUSCLE TUMORS; PHASE-II TRIAL; T-CELLS; AIDS; TRANSPLANTATION; GEMCITABINE; DOCETAXEL; INFECTION;
D O I：
10.1097/MPH.0b013e3181c80bf3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 17-year-old African American female with human immunodeficiency virus infection presented with an unresectable intracranial neoplasm with mass effect upon the brainstem. Stereotactic biopsy revealed an Epstein-Barr virus (EBV)-associated leiomyosarcoma. Radiation therapy and gemcitabine were used to shrink the mass with the aim to make it surgically resectable. Prolonged neutropenia and recurrent skin infections led to the discontinuation of gemcitabine. The mass stabilized after radiation therapy and has decreased in size in 15 months of follow-up. EBV has been demonstrated in most smooth muscle tumors associated with acquired immunodeficiency syndrome and other immunocompromised states. This is the first documented case of an EBV-positive intracranial leiomyosarcoma in a pediatric human immunodeficiency virus patient.
引用
收藏
页码：E144 / E147
页数：4
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