Penarolide sulfates A1 and A2, new α-glucosidase inhibitors from a marine sponge Penares sp.

被引：33
|
作者：
Nakao, Y
Maki, T
Matsunaga, S
van Soest, RWM
Fusetani, N [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan
[2] Univ Amsterdam, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands
来源：
TETRAHEDRON | 2000年 / 56卷 / 46期
关键词：
enzyme inhibitors; macrolides; marine metabolites; mass spectrometry; sponge;
D O I：
10.1016/S0040-4020(00)00750-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Penarolide sulfates A(1) (1) and A(2) (2) have been isolated as alpha -glucosidase inhibitors from a marine sponge Penares sp.(1) Their structures including absolute stereochemistry were determined to be unique 30- and 31-membered macrolides encompassing a proline residue and three sulfate groups by interpretation of spectral data and chemical degradation. Penarolide sulfates Al (1) and A2 (2) inhibit alpha -glucosidase with IC50 values of 1.2 and 1.5 mug/mL, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8977 / 8987
页数：11
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