A concise route to the core pentasaccharide of N-linked glycoproteins

被引：38
|
作者：
Dudkin, VY
Miller, JS
Danishefsky, SJ
机构：
[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA
[2] Columbia Univ, Dept Chem, New York, NY 10027 USA
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 09期
关键词：
D O I：
10.1016/S0040-4039(03)00101-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise preparation of the common pentasaccharide core of the N-linked glycoproteins is described. The reducing end glycal is functionalized at the level of chitobiose, which is then beta-mannosylated using Crich's direct coupling protocol. Deprotection of the branching mannose residue, and di-alpha-mannosylation complete the synthesis. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1791 / 1793
页数：3
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