Effects of VIP and related peptides on airway mucus secretion from isolated rat trachea

被引：24
|
作者：
Wagner, U [1 ]
Bredenbroker, D [1 ]
Storm, B [1 ]
Tackenberg, B [1 ]
Fehmann, HC [1 ]
Von Wichert, P [1 ]
机构：
[1] Univ Marburg, Dept Med, Clin Res Unit Gastrointestinal Endocrinol, D-35033 Marburg, Germany
来源：
PEPTIDES | 1998年 / 19卷 / 02期
关键词：
VIP; PHI; PACAP; GLP-I; exendin; helodermin; helospectin; mucus secretion; thiorphan;
D O I：
10.1016/S0196-9781(97)00257-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vasoactive intestinal polypeptide (VIP) is known as an important regulator of ah-way function. It has been suggested that VIP is involved in the pathogenesis of asthma due to its relaxant effects on smooth muscles. The present study was designed to characterize the effects of the peptides of the VIP family on airway mucus secretion. The peptides VIP, PI-II, PACAP-27, PACAP-38, GLP-I, exendin-4, helodermin, helospectin I and helospectin II were investigated using isolated rat trachea. Data show that PACAP-27 is the most potent stimulator of airway mucus secretion (225% stimulation). The rank order of potency was PACAP-27 > VIP > helospectin II > Pi-II > exendin-4 = helodermin = helospectin I = PACAP-38. The addition of the protease inhibitor thiorphan enhanced the effects of PI-II and helodermin, but not of the other peptides. These data show that the peptides of the VIP family stimulate airway mucus secretion differently. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：241 / 245
页数：5
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