Rhodium-catalyzed asymmetric synthesis of 3,3-disubstituted 1-indanones

被引：77
|
作者：
Shintani, Ryo [1 ]
Takatsu, Keishi [1 ]
Hayashi, Tamio [1 ]
机构：
[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 20期
关键词：
alkynes; asymmetric catalysis; boron; indanones; rhodium; 3-SUBSTITUTED INDANONES; KINETIC RESOLUTION; BOND-CLEAVAGE; KETONES;
D O I：
10.1002/anie.200700226
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Rapid access to enantioenriched indanones that are difficult to obtain by other methods is gained through the highly enantioselective addition of aryl boronates to aryl alkynyl ketones under rhodium catalysis (see scheme). The resulting 3,3-disubstituted 1-indanones can be converted into a range of potentially useful indan derivatives with high stereoselectivity. R1 = Si(alkyl)3, GeEt3; R2 = F, Me, OMe; cod = 1,5-cyclooctadiene. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3735 / 3737
页数：3
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