CD5 CAR T-Cells Avoid Self-Elimination by Continuously Degrading CD5 Protein

被引:0
|
作者
Ma, Royce [1 ]
Popat, Divya [1 ]
Chaumette, Alex [1 ]
Carisey, Alexandre [2 ]
McKenna, Mary K. [1 ]
Srinivasan, Madhuwanti [1 ]
Watanabe, Norihiro [1 ]
Brenner, Malcolm K. [1 ]
Mamonkin, Maksim [1 ]
机构
[1] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
[2] Baylor Coll Med, Pediat, Houston, TX 77030 USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
72
引用
收藏
页码:36 / 36
页数:1
相关论文
共 50 条
  • [1] T-cells resist CD5 CAR mediated fratricide by continuously degrading CD5 protein
    Ma, Royce
    Popat, Divya
    Chaumette, Alex
    Carisey, Alexandre
    Brenner, Malcolm K.
    Mamonkin, Maksim
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [2] Mitigating the CD5 CAR-CD5 interaction enhances the functionality of CD5 CAR-T cells by alleviating the T-cell fratricide
    Ho, Lee Young
    Yu, Seung Rok
    Jeong, Hoon Jeong
    Lee, Hyeong Ji
    Cho, Hyeon Jeong
    Kim, Hyung Cheol
    CANCER RESEARCH, 2023, 83 (07)
  • [3] A Ligand for CD5 Is CD5
    Brown, Marion H.
    Lacey, Erica
    JOURNAL OF IMMUNOLOGY, 2010, 185 (10): : 6068 - 6074
  • [4] Blood group antibodies are made by CD5(+) and by CD5(-) B cells
    Wuttke, NJ
    MacArdle, PJ
    Zola, H
    IMMUNOLOGY AND CELL BIOLOGY, 1997, 75 (05): : 478 - 483
  • [5] CD5 CAR T-Cells for Treatment of Patients with Relapsed/Refractory CD5 Expressing T-Cell Lymphoma Demonstrates Safety and Anti-Tumor Activity
    Hill, LaQuisa
    Rouce, Rayne Helen
    Smith, Tyler S.
    Yang, Lina
    Srinivasan, Madhuwanti
    Zhang, Huimin
    Perconti, Silvana
    Mehta, Birju
    Dakhova, Olga
    Randall, Josalind
    Grilley, Bambi
    Heslop, Helen E.
    Brenner, Malcolm K.
    Mamonkin, Maksim
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (03) : S237 - S238
  • [6] Mechanisms Regulating the Resistance of Normal T-cells to CD5 CAR-Mediated Cytotoxicity
    Ma, Royce
    Woods, Mae L.
    Chaumette, Alex
    Popat, Divya
    Carisey, Alexandre
    Brenner, Malcolm K.
    Mamonkin, Maksim
    MOLECULAR THERAPY, 2022, 30 (04) : 56 - 56
  • [7] MECHANISMS REGULATING THE RESISTANCE OF NORMAL T-CELLS TO CD5 CAR-MEDIATED CYTOTOXICITY
    Ma, R.
    Woods, M. L.
    Chaumette, A.
    Popat, D.
    Carisey, A.
    Brenner, M.
    Mamonkin, M.
    CYTOTHERAPY, 2022, 24 (05) : S39 - S39
  • [8] DIFFERENTIAL REGULATION OF CD5 AND CD4 MOLECULES ON HUMAN T-CELLS
    PAAVONEN, T
    MACKENZIE, L
    DELVES, PJ
    LUND, T
    LYDYARD, PM
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1989, 30 (05) : 644 - 644
  • [9] A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5
    Bikah, G
    Lynd, FM
    Aruffo, AA
    Ledbetter, JA
    Bondada, S
    INTERNATIONAL IMMUNOLOGY, 1998, 10 (08) : 1185 - 1196
  • [10] CD5 CAR for the Treatment of T-Cell Malignancies
    Mamonkin, Maksim
    Brenner, Malcolm K.
    MOLECULAR THERAPY, 2015, 23 : S162 - S163